Neurology – Page 3

Incidental DWI-Positive Lesions as Emerging Biomarkers in Cerebral Small Vessel Disease: Insights from CAA and CADASIL Cohorts

By MedXY 06/28/2026

Incidental DWI-positive lesions are prevalent in cerebral amyloid angiopathy and CADASIL, showing disease-specific distributions and associations with neurodegeneration and MRI biomarkers. These findings underscore their potential role as markers of small vessel disease.

Internal Medicine Neurology news

Harnessing Acoustic Analysis in Primary Care to Detect Cognitive Impairment: A Novel Screening Approach

By MedXY 06/28/2026

Machine learning analysis of brief patient-physician conversations using acoustic speech features can effectively screen for cognitive impairment in primary care settings, enabling scalable early detection.

Neurology news

Successful Recanalization Boosts Functional Recovery in Minor Ischemic Stroke: Insights from the TEMPO-2 Trial

By MedXY 06/27/2026

Secondary analysis of the TEMPO-2 trial reveals that successful recanalization significantly improves 90-day functional outcomes in minor ischemic stroke patients with proven occlusion, with tenecteplase markedly enhancing recanalization rates compared to standard care.

Neurology news

Distinct Early Cerebral Edema Subtypes as Predictors of Outcome in Cerebral Venous Thrombosis: Insights from the CLOT-VENUS Registry

By MedXY 06/27/2026

This study identifies global and cytotoxic cerebral edema subtypes in cerebral venous thrombosis as key determinants of poor functional outcomes and mortality, providing new avenues for early risk stratification and targeted adjunctive therapies.

Clinical Updates Neurology news

Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia: An Integrative Review

By MedXY 06/27/2026

This review synthesizes current evidence on CSF TMEM106B levels in FTLD, highlighting their associations with disease severity, genetic variants, brain atrophy, and clinical progression, emphasizing TMEM106B's potential as a biomarker and mechanistic insight into neurodegeneration.

Internal Medicine Neurology news

Navigating Complex Decisions: Physician Strategies in Setting Stroke Care Goals for Patients with Preexisting Disability or Dementia

By MedXY 06/25/2026

This article explores how physicians determine stroke care goals for patients with disability or dementia, highlighting key challenges, decision factors, and the need for individualized, bias-aware approaches.

Neurology news OB/GYN & Women’s Health

Influence of Parity on Cognitive Decline and Hippocampal Atrophy in Amyloid-Positive Postmenopausal Women

By MedXY 06/25/2026

Higher parity in cognitively unimpaired postmenopausal women with positive β-amyloid status is linked to accelerated cognitive decline and hippocampal volume reduction, suggesting parity modulates resilience to Alzheimer’s pathology in preclinical stages.

Clinical Updates General Surgery Neurology news

Long-Term Mortality, Cognition, and Quality of Life After Chronic Subdural Hematoma Surgery: A Comprehensive Review

By MedXY 06/24/2026

This review synthesizes evidence on the long-term survival, excess mortality, and health-related quality of life in patients after chronic subdural hematoma surgery, emphasizing sustained mortality risks and cognitive-physical deficits up to 10 years postoperatively.

Critical Care Neurology news

When Does an ICP Crisis Really Count? BOOST II Raises Questions About Bedside Detection in Severe TBI

By MedXY 06/19/2026

A post hoc BOOST II analysis found that many bedside-labeled intracranial pressure crises were not confirmed by continuous electronic data, challenging current ICP episode definitions in severe traumatic brain injury.

Neurology news Ophthalmology

Retinal Microvascular Clues to Alzheimer Disease: What Swept-Source OCT Angiography Reveals About Neurovascular Dysfunction

By MedXY 06/19/2026

SS-OCTA identified retinal and choriocapillaris microvascular changes associated with cognitive status in Alzheimer disease, including thinner GCC in dementia and a biphasic CCFD pattern, suggesting a promising noninvasive biomarker platform.

Neurology news

A New Way to Measure Prodromal Synucleinopathy: What the PSRS Adds for RBD Clinical Trials

By MedXY 06/17/2026

The PSRS showed good-to-excellent reliability and moderate-to-strong construct validity in a large RBD cohort, supporting its use as a multidomain measure of prodromal synucleinopathy burden.

Neurology news Public Health

Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study

By MedXY 06/17/2026

The POINTER Imaging study found no overall brain biomarker changes from a structured lifestyle intervention, but participants with lower baseline hippocampal volume showed greater cognitive benefit, suggesting imaging may help identify who responds best.

Cardiology Neurology news

Multiple Sclerosis Does Not Appear to Worsen In-Hospital Outcomes After Cardiovascular Surgery, but Routine Home Discharge Is Less Common

By MedXY 06/11/2026

A large US inpatient analysis found similar in-hospital mortality and complication rates after cardiovascular surgery in patients with and without multiple sclerosis, but patients with MS were less often discharged routinely home.

Emergency Medicine Neurology news

Ultra-Early Remote Ischemic Postconditioning After Thrombectomy Appears Safe but Does Not Improve 90-Day Stroke Recovery

By MedXY 06/10/2026

In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.

Neurology news OB/GYN & Women’s Health

Postmenopausal Migraine Signals Higher Ischemic Stroke Risk, Not Hemorrhagic Stroke, in the Women’s Health Initiative

By MedXY 06/10/2026

In a large cohort of postmenopausal women, migraine history was associated with a modest increase in ischemic stroke risk over 20 years, while total and hemorrhagic stroke risks were not significantly elevated.

Cardiology Neurology news

Hypertension-Related High-Risk Features May Identify Which Patients With Cryptogenic Stroke Benefit From Apixaban Instead of Aspirin

By MedXY 06/10/2026

An exploratory ARCADIA analysis suggests that patients with cryptogenic stroke and atrial cardiopathy without severe hypertension-related features may derive greater benefit from apixaban than aspirin, whereas those with high-risk hypertensive features may not.

Neurology news Radiology

Wider Intracranial Arteries, Not Cranial Arterial Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease

By MedXY 06/10/2026

In a prospective mild stroke cohort, cranial arterial stenosis was not linked to cSVD, whereas basilar dolichoectasia and wider intracranial arteries were strongly associated with lacunar stroke, higher cSVD burden, incident infarcts, and white matter lesion progression.

Neurology news

Identification of Genetic Modifiers of Autosomal Dominant Alzheimer’s Disease: A Genome-Wide Association Study

By MedXY 06/10/2026

A genome-wide study identified three genetic modifiers of autosomal dominant Alzheimer’s disease, linking them to disease risk, earlier onset, and biomarker changes involving amyloid, tau, TDP-43, and brain aging.

$Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus$

Critical Care Neurology news

Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus

By MedXY 06/10/2026

This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.

Cardiology Neurology news

Acute Cardiac CT Added to Stroke Imaging Detects Cardiac Thrombi in About 1 in 16 Patients and Outperforms Transthoracic Echocardiography

By MedXY 06/10/2026

In a 3919-patient individual-level meta-analysis, acute cardiac CT detected cardiac thrombi in 6.2% of ischemic stroke cases, exceeded transthoracic echocardiography yield, added modest imaging burden, and identified patients with worse 90-day outcomes.