Neurology – Page 2

Unraveling Alzheimer’s Disease Progression in Down Syndrome via Blood Proteome Dynamics

By MedXY 09/05/2026

Longitudinal analysis of blood proteins reveals distinctive trajectories and associations with cognitive decline in adults with Down syndrome, shedding light on Alzheimer's disease pathophysiology in this high-risk group.

Neurology news

Evaluating Tirofiban Plus Aspirin in Branch Atheromatous Disease Stroke: Insights from the STRATEGY Trial

By MedXY 09/05/2026

The STRATEGY trial assessed whether combining tirofiban with aspirin improves outcomes in branch atheromatous disease (BAD)-related stroke but found no significant benefit over aspirin alone in preventing neurological deterioration or recurrent stroke.

Clinical Updates Neurology news Pediatrics

Safety and Efficacy of Guanabenz in Early-Childhood Onset Vanishing White Matter: Insights from a Phase 1/2 Single-Arm Trial

By MedXY 09/05/2026

This review synthesizes recent evidence demonstrating guanabenz's manageable safety profile and efficacy in delaying ambulatory decline in early-onset vanishing white matter disease, highlighting translational pharmacokinetic data and clinical outcomes.

Neurology news OB/GYN & Women's Health

Antiseizure Medication Use During Pregnancy: Implications for Fetal Growth from the EURAP Registry

By MedXY 09/05/2026

A comprehensive cohort study from the EURAP registry reveals that antiseizure medication, especially polytherapy and certain monotherapies, increases the risk of poor fetal growth, underscoring the need for optimized treatment strategies during pregnancy.

Neurology news Radiology

Revolutionizing Stroke Diagnosis: Noninvasive Thrombus Imaging with [18F]GP1 PET/CT

By MedXY 09/04/2026

A novel noninvasive imaging technique using [18F]GP1 PET/CT enables direct identification of thrombi in acute ischemic stroke, improving etiologic classification and predicting recurrence risk, heralding mechanism-based stroke management.

Neurology news Pediatrics

Prenatal Organophosphate Exposure and Autism Traits: A Large-Scale Cohort Study Finds No Association

By MedXY 09/04/2026

This large prospective cohort study found no significant association between prenatal organophosphate pesticide exposure and autism-related traits in children, after comprehensive adjustments including maternal diet and sociodemographic factors.

Dermatology Neurology news

Cherry Angiomas as a Novel Vascular Manifestation in Neurofibromatosis Type 1: Epidemiology and Mechanistic Insights

By MedXY 09/03/2026

Cherry angiomas are significantly more prevalent and occur at younger ages in individuals with Neurofibromatosis Type 1 (NF1), linked to biallelic NF1 inactivation in vascular cells. This discovery expands the vascular phenotype of NF1 and provides a new model for NF1-related vasculopathy.

Gastroenterology Neurology news Transplantation

Metabolite-Mediated Neurocognitive Revival Following Liver Transplantation: Insights into Cortical Network Reactivation

By MedXY 09/03/2026

Liver transplantation facilitates early neurocognitive recovery in end-stage liver disease patients by restoring cortical network activities, with S-methyl-5'-thioadenosine playing a pivotal neuroprotective role through modulating neuroinflammation.

Neurology news Otorhinolaryngology

Variable Effects of Vagus Nerve Stimulator Cycling on Vocal Fold Motion: A Videographic Case Series

By MedXY 08/31/2026

This case series examines eight patients experiencing dysphonia after vagus nerve stimulator placement, highlighting variable and transient vocal fold motion changes during device cycling.

Hematology-Oncology Neurology news

Recent Mechanical Venous Thrombosis Risk Factors and Their Role in Young-Onset Cryptogenic Ischemic Stroke: New Insights from the SECRETO Study

By MedXY 08/31/2026

This multicenter study reveals that recent mechanical venous thrombosis risk factors markedly increase the risk of cryptogenic ischemic stroke in young adults, especially in those under 40 and with patent foramen ovale, independent of thrombophilic markers.

Hematology-Oncology Neurology news

Recent Mechanical Venous Thrombosis Risk Factors and Their Role in Young-Onset Cryptogenic Ischemic Stroke

By MedXY 08/30/2026

This multicenter study reveals that recent mechanical venous thrombosis risk factors within 14 days significantly increase the risk of cryptogenic ischemic stroke in young adults, notably in those under 40 and with patent foramen ovale, independent of thrombophilia markers.

Cardiology Neurology news

RNF213 p.R4810K Variant: A Novel Independent Genetic Risk Factor for Extracranial Carotid Artery Disease

By MedXY 08/30/2026

The RNF213 p.R4810K variant independently increases risk and severity of extracranial carotid artery disease, distinct from its known association with intracranial atherosclerosis, highlighting new insights into vascular disease genetics and stroke risk assessment.

Neurology news Radiology

Unraveling White Matter Hyperintensities: Distinct Lesion Subtypes Reveal Diverse Clinical Implications Beyond Location

By MedXY 08/30/2026

Advanced MRI analyses identify three biologically distinct subtypes of white matter hyperintensities (WMHs), linking specific lesion evolution patterns with neurodegeneration and vascular/metabolic risks, offering refined insights into cerebrovascular contributions to aging and neurodegenerative diseases.

Neurology news

Severe Parsonage-Turner Syndrome vs. Traumatic Brachial Plexopathy: Insights into Motor Recovery and Treatment Outcomes

By MedXY 08/30/2026

This study compares motor-unit reinnervation and functional recovery in severe Parsonage-Turner syndrome and surgically managed traumatic brachial plexopathy, highlighting spontaneous recovery in PTS and benefits of early reconstruction in TBP.

Cardiology Neurology news

Higher Stroke and TIA Risk With Pulsed Field Ablation Compared to Radiofrequency Ablation in Atrial Fibrillation: Insights From a Large Prospective Registry

By MedXY 08/28/2026

This prospective registry reveals a significantly increased risk of stroke or transient ischemic attack within 30 days after pulsed field ablation compared to radiofrequency ablation for atrial fibrillation, highlighting important safety considerations and the need for careful surveillance.

Diabetes & Endocrinology Neurology news

Unveiling Neuroimaging Patterns and Genotype-Phenotype Links in Noonan Syndrome: Insights from a Multicenter Cohort

By MedXY 08/28/2026

A comprehensive multicenter study reveals frequent neuroimaging abnormalities in children with Noonan syndrome and elucidates their associations with genetic variants and neurological symptoms, enhancing understanding of brain involvement in this RASopathy.

Neurology news Pediatrics

Expanding Horizons: Eligibility and Implications of Thrombolysis in Pediatric Acute Ischemic Stroke

By MedXY 08/28/2026

This study evaluates the eligibility of children with acute ischemic stroke (AIS) for thrombolysis with tPA, revealing only 19% potential eligibility under current guidelines, and highlights opportunities to reconsider treatment in small-vessel AIS.

Neurology news

MRI-Derived EOAD-Signature Atrophy as a Prognostic Biomarker in Early-Onset Mild Cognitive Impairment

By MedXY 08/28/2026

Baseline cortical atrophy within an EOAD-specific brain signature predicts progression from mild cognitive impairment to dementia, providing a valuable MRI biomarker for individualized prognosis in early-onset Alzheimer disease.

Critical Care Neurology news

Body Weight and Alteplase Efficacy in Acute Ischemic Stroke: Insights from the ENCHANTED Trial

By MedXY 08/28/2026

The ENCHANTED trial post hoc analysis reveals body weight does not alter alteplase dose effectiveness in acute ischemic stroke, but low body weight independently predicts poorer outcomes without increased hemorrhagic risk.

Neurology news

Unveiling Metabolic Signatures: Glucose and Methionine PET Imaging in Disorders of Consciousness Post-Brain Injury

By MedXY 08/26/2026

This exploratory longitudinal study reveals that alongside decreased glucose metabolism, elevated brainstem methionine uptake correlates with consciousness improvement in brain-injured patients, highlighting novel metabolic biomarkers for prognosis in disorders of consciousness.