Why Women Show Higher Amyloid Burden: New Evidence on Sex, Race, and APOE ε4 Interactions in Alzheimer’s Pathology
Posted inNeurology news Pathology & Lab Medicine/Bệnh học

Why Women Show Higher Amyloid Burden: New Evidence on Sex, Race, and APOE ε4 Interactions in Alzheimer’s Pathology

A Brazilian autopsy study of 2,268 individuals reveals that female sex, APOE ε4 status, and African ancestry jointly influence amyloid pathology. Women showed 65% higher adjusted odds of neuritic plaques, and protective effects against amyloid in Black individuals were attenuated by APOE ε4 carriage, highlighting critical disparities in Alzheimer's disease pathogenesis.
Mobile Health Intervention Achieves 24% Better Blood Pressure Control in Stroke Survivors: PINGS Trial Results from Ghana
Posted inCardiology Neurology news

Mobile Health Intervention Achieves 24% Better Blood Pressure Control in Stroke Survivors: PINGS Trial Results from Ghana

The PINGS trial demonstrates that a 12-month nurse-led mobile health intervention significantly improves blood pressure control among Ghanaian stroke survivors, with 67% achieving target BP versus 43% in usual care. This pragmatic approach leveraging task-shifting and basic mHealth tools offers a scalable model for resource-limited settings.
Timing of Atrial Fibrillation Diagnosis Does Not Alter Early Anticoagulation Benefits in Stroke Patients: Insights from the OPTIMAS Trial
Posted inCardiology Neurology news

Timing of Atrial Fibrillation Diagnosis Does Not Alter Early Anticoagulation Benefits in Stroke Patients: Insights from the OPTIMAS Trial

Subgroup analysis of the OPTIMAS trial reveals that neither the timing of atrial fibrillation diagnosis nor AF subtype modifies the treatment effect of early versus delayed direct oral anticoagulant initiation in acute ischemic stroke. Persistent AF, however, confers approximately double the risk of adverse outcomes compared with paroxysmal AF.
Normative Modeling Exposes Hidden Individual Variability in Traumatic Brain Injury: A New Frontier for Personalized Neuroimaging Assessment
Posted inNeurology news Radiology

Normative Modeling Exposes Hidden Individual Variability in Traumatic Brain Injury: A New Frontier for Personalized Neuroimaging Assessment

A landmark study of 631 participants reveals that normative modeling uncovers substantial individual heterogeneity in brain morphology following traumatic brain injury that conventional group-based analyses miss, with every patient exhibiting unique neuroanatomical deviation patterns that correlate with injury severity.
Beyond Communication: Language Barriers Linked to Higher Hospital Utilization at End-of-Life in Dementia
Posted inNeurology news Public Health

Beyond Communication: Language Barriers Linked to Higher Hospital Utilization at End-of-Life in Dementia

A retrospective cohort study reveals that dementia patients with preferred language other than English are more likely to have documented goals-of-care discussions yet experience significantly higher hospital-based healthcare utilization near end-of-life, including increased ED visits, hospitalizations, ICU admissions, and in-hospital deaths.