Respiratory system elastance (ERS) significantly modifies how tidal volume (VT) and respiratory rate influence clinical outcomes in acute brain injury patients on mechanical ventilation.
Higher VT is linked to lower ICU mortality in patients with low ERS, but this benefit dissipates in those with high ERS.
An increased respiratory rate correlates with worse outcomes, particularly at low ERS; this association weakens as elastance increases.
Optimal ventilator settings should balance driving pressure (ΔP) and respiratory rate to maintain adequate alveolar ventilation while minimizing harm.
