Designing Rigorous Trials of Systemic Therapy with Surgery and Locoregional Treatment in Hepatocellular Carcinoma: Key Recommendations from an HCC-Live Expert Consensus

Designing Rigorous Trials of Systemic Therapy with Surgery and Locoregional Treatment in Hepatocellular Carcinoma: Key Recommendations from an HCC-Live Expert Consensus

A multidisciplinary consensus provides practical, trial-design focused recommendations for testing systemic therapies around surgery or combined with locoregional treatment in hepatocellular carcinoma, emphasizing patient selection, endpoints, safety, and statistical strategies.
Diabetes Duration and Advanced Diabetes-Related Complications in Lower-Extremity Versus Coronary Revascularization: A Comparative Review

Diabetes Duration and Advanced Diabetes-Related Complications in Lower-Extremity Versus Coronary Revascularization: A Comparative Review

This review synthesizes evidence comparing diabetes duration and advanced complications between patients undergoing revascularization for lower extremity artery disease (LEAD) and coronary artery disease (CAD), highlighting the heavier diabetes burden in LEAD patients despite similar glycemic control.
Bridging the Gap: Advancing Automated Insulin Delivery for Pregnant Women with Type 1 Diabetes

Bridging the Gap: Advancing Automated Insulin Delivery for Pregnant Women with Type 1 Diabetes

Automated insulin delivery (AID) systems, while transformative for type 1 diabetes management, currently lack pregnancy-specific adaptations, leaving a critical gap in care. This article highlights the urgent need to include pregnant women in AID research and develop pregnancy-optimized systems to improve maternal and perinatal outcomes.