Highlight
- Prophylactic cryotherapy markedly reduces retinal detachment risk in genetically confirmed Type 2 Stickler syndrome patients.
- The Cambridge protocol demonstrated a 3- to 10-fold reduction in detachment risk compared to untreated controls.
- No serious long-term adverse effects were observed, supporting the safety of the intervention.
- This study extends prophylactic efficacy evidence from Type 1 to Type 2 Stickler syndrome, suggesting broader applicability.
