Small extracellular vesicles (sEVs) derived from peritoneal fluid (PF) contain distinct proteins differentially expressed in women with and without endometriosis.
Four proteins—ALDOA, HSP90AA1, COL15A1, and S100-A10—show significant differences, suggesting their potential as disease-specific biomarkers.
Protein alterations in sEVs are consistent regardless of menstrual cycle phase or severity of endometriosis, supporting their utility as stable markers.
Larger studies and functional analyses are needed to validate these findings and explore sEV roles in endometriosis pathophysiology and non-invasive diagnostics.
