Awake Integrated Microsurgical Approach for Head and Neck Free Flap Reconstruction in Frail Patients: A Safe and Resource-Efficient Alternative to General Anesthesia

Awake Integrated Microsurgical Approach for Head and Neck Free Flap Reconstruction in Frail Patients: A Safe and Resource-Efficient Alternative to General Anesthesia

This retrospective study compares awake loco-regional anesthesia with sedation (AIM) against general anesthesia for head and neck free flap reconstruction, demonstrating AIM's safety, reduced operative time, and lower ICU use in frail patients.
International Validation of Sepsis Temperature-Trajectory Subphenotypes Reveals Immune and Coagulation Profiles with Implications for Immunoglobulin Therapy

International Validation of Sepsis Temperature-Trajectory Subphenotypes Reveals Immune and Coagulation Profiles with Implications for Immunoglobulin Therapy

This study validates temperature-trajectory sepsis subphenotypes in a large Chinese ICU cohort, linking immune and coagulation dysfunction with mortality and highlighting differential responses to immunoglobulin therapy, particularly benefit in hypothermic patients.
Decoding Structure-Function Links in Early Atrophic Age-Related Macular Degeneration: Implications for Targeted Assessment and Management

Decoding Structure-Function Links in Early Atrophic Age-Related Macular Degeneration: Implications for Targeted Assessment and Management

This study reveals distinct structure-function correlations in early atrophic AMD, showing lesion size correlates with localized sensitivity loss, while lesion proximity to the fovea predicts central vision and reading outcomes, supporting the use of targeted functional assessments in clinical practice.
Impact of Intraoperative Recurrent Laryngeal Nerve Monitoring on Post-Thyroidectomy Airway Outcomes: Insights from a Large National Cohort

Impact of Intraoperative Recurrent Laryngeal Nerve Monitoring on Post-Thyroidectomy Airway Outcomes: Insights from a Large National Cohort

This study demonstrates that intraoperative recurrent laryngeal nerve monitoring during thyroid surgery is independently associated with reduced postoperative airway complications, especially benefiting high-risk patients with significant comorbidities and advanced disease.