Gastroenterology – Page 2

Robotic Versus Laparoscopic Complex Elective Cholecystectomy: Balancing Outcomes and Costs

By MedXY 07/17/2026

Robotic cholecystectomy for complex gallbladder disease reduces postoperative complications and interventions compared to laparoscopic surgery without increasing total costs, suggesting a strategic role for robotic platforms in complex cases.

Gastroenterology Internal Medicine news

Global Variability in Non-Invasive Testing Accuracy for MASLD: Key Findings from the G-MASLD Study

By MedXY 07/16/2026

The G-MASLD study evaluated the diagnostic accuracy of non-invasive fibrosis tests across 41 countries, revealing regional variability and identifying Agile-3+ and Agile-4 as the most accurate for advanced fibrosis and cirrhosis in MASLD patients.

Gastroenterology news Oncology

Targeting SOX9-Driven SPEM Plasticity: A New Therapeutic Avenue to Prevent Gastric Cancer Progression

By MedXY 07/16/2026

SOX9 is a pivotal regulator of SPEM cell plasticity driving gastric metaplasia and carcinogenesis. Therapeutically targeting SOX9 may prevent the progression of pre-cancerous lesions to gastric cancer by blocking metaplastic evolution.

Gastroenterology General Surgery news

Outcomes of Colorectal Dysplasia and Cancer in Patients with PSC-IBD Undergoing Liver Transplantation and Colectomy: Insights from a Multicenter Study

By MedXY 07/15/2026

This multicenter retrospective study examines colorectal dysplasia and malignancy outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease undergoing liver transplantation and colectomy, revealing comparable 5-year survival despite advanced disease in those transplanted first.

Diabetes & Endocrinology Gastroenterology news

EndoBarrier Duodenal-Jejunal Bypass Liner: A Novel Endoscopic Adjunct for Improved Glycemic Control and Weight Loss in Type 2 Diabetes with Obesity

By MedXY 07/15/2026

The ENDO trial demonstrates that the EndoBarrier duodenal-jejunal bypass liner significantly improves glycemic control and induces meaningful weight loss in patients with poorly controlled type 2 diabetes and obesity, with an acceptable safety profile.

Gastroenterology news Pediatrics

Reclassifying Pediatric NAFLD: Insights from the Steatotic Liver Disease Framework in a Multicenter NASH CRN Study

By MedXY 07/15/2026

A multicenter study reclassifies pediatric NAFLD under the steatotic liver disease framework, revealing most children meet MASLD criteria, while highlighting alcohol and medication-related reclassifications that inform diagnosis and management.

Gastroenterology news Oncology

Long-term Risk of Hepatocellular Carcinoma After Clearance of Hepatitis B Surface Antigen

By MedXY 07/14/2026

This study evaluates the long-term incidence of liver cancer in chronic hepatitis B patients who clear hepatitis B surface antigen, finding significantly reduced cancer risk in younger patients without cirrhosis.

Cardiology Gastroenterology news

Microplastic Exposure and Cardiomyopathy: Unveiling the Gut-Heart Axis Mechanism

By MedXY 07/14/2026

This study reveals that bisphenol F exposure aggravates cardiomyopathy under hemodynamic stress through gut microbiota metabolism, highlighting a novel gut-heart axis involving N-acetylputrescine and potential therapeutic targets.

Gastroenterology news Oncology

Optimizing Prognostic Accuracy in Duodenal Adenocarcinoma: Evaluating Lymph Node Staging Schemes and a Novel Nomogram

By MedXY 07/13/2026

This study identifies log odds of positive lymph nodes as the superior prognostic parameter in duodenal adenocarcinoma and introduces a validated nomogram that integrates this metric with clinical factors to improve individualized survival predictions.

Gastroenterology news Pediatrics

Serum Bile Acid Levels as Early Predictors of Portal Hypertension and Esophageal Varices Post-Kasai in Biliary Atresia

By MedXY 07/13/2026

Serum bile acid levels measured within the first year after Kasai procedure accurately predict portal hypertension and high-risk esophageal varices development within five years in biliary atresia patients, offering a valuable non-invasive prognostic biomarker.

Gastroenterology Internal Medicine news

Unraveling IBS Genetics: Insights into Cardiometabolic and Triglyceride-Linked Mechanisms from a Large GWAS Meta-Analysis

By MedXY 07/13/2026

A genome-wide meta-analysis of 2.8 million individuals reveals genetic links between irritable bowel syndrome, brain-gut pathways, and cardiometabolic traits, highlighting novel therapeutic targets involving triglyceride metabolism.

Gastroenterology news

Evaluating Dose Intensification Strategies for Ustekinumab in Crohn’s Disease: Insights from the REScUE Trial

By MedXY 07/13/2026

The REScUE study compared two ustekinumab dosing intensification regimens after secondary loss of response in Crohn’s disease, finding no superiority of more frequent dosing regarding steroid-free remission at 48 weeks.

Gastroenterology news Oncology

Durvalumab Plus Chemotherapy Extends Survival in Advanced Biliary Tract Cancer: Insights from the TOPAZ-1 Trial Four-Year Post Hoc Analysis

By MedXY 07/12/2026

A four-year post hoc analysis of the TOPAZ-1 trial confirms that durvalumab combined with gemcitabine and cisplatin offers a long-term survival benefit with manageable safety as first-line treatment for advanced biliary tract cancer.

Gastroenterology General Surgery news

Sustained Quality of Life After Pancreatic Surgery for IPMNs in Young Patients: Long-Term Data and Clinical Implications

By MedXY 07/11/2026

Young patients undergoing resection for intraductal papillary mucinous neoplasms (IPMNs) exhibit excellent long-term quality of life comparable to the general population despite endocrine and exocrine insufficiencies.

Gastroenterology General Surgery news

Refining Pancreatic Cystic Neoplasm Assessment: The Incremental Role of Endoscopic Ultrasound and Fine Needle Aspiration

By MedXY 07/11/2026

This study evaluates the added value of endoscopic ultrasound (EUS) and fine needle aspiration (FNA) after MRI in assessing pancreatic cystic neoplasms, demonstrating significant improvement in diagnostic specificity and clinical decision-making, especially for lesions without high-risk MRI features.

Gastroenterology Infectious Diseases news

Unraveling Hepatitis B-Induced Liver Fibrosis: The Critical Role of Pyruvate, PPARα, and Reactive Oxygen Species

By MedXY 07/10/2026

This article explores the mechanism by which HBV induces liver fibrosis through pyruvate-dependent ROS production and PPARα inhibition, highlighting novel therapeutic targets for chronic hepatitis B management.

Gastroenterology news Pediatrics

Unveiling the Role of IL-10-Neutralising Autoantibodies in Pediatric-Onset Inflammatory Bowel Disease: Prevalence, Persistence, and Clinical Implications

By MedXY 07/10/2026

This study reveals that IL-10-neutralising autoantibodies occur in 2.1% of pediatric IBD cases without monogenic causes, persist over years, and may define a distinct clinical subgroup with specific therapeutic needs.

Gastroenterology General Surgery news

Decoding Microbial Shifts in Postoperative Crohn’s Disease: Insights into Recurrence Dynamics

By MedXY 07/10/2026

This article explores how mucosa-associated microbiota changes after ileal resection in Crohn’s disease correlate with postoperative recurrence, highlighting microbial signatures and dynamic ecosystem changes along the Rutgeerts score.

Gastroenterology news Otorhinolaryngology

Antireflux Diet Versus Medication: A Comparative Analysis in Laryngopharyngeal Reflux Disease Management

By MedXY 07/08/2026

This study evaluates the effectiveness of an antireflux diet combined with stress reduction against proton pump inhibitors, alginates, and antacids in treating laryngopharyngeal reflux disease, revealing diet adherence may offer superior symptom relief.

Gastroenterology General Surgery news

Impact of Modified Frailty Index on Liver Transplant Outcomes: Insights from a Multicenter Cohort Study

By MedXY 07/08/2026

This study demonstrates that the 5-variable Modified Frailty Index effectively predicts short- and long-term morbidity and mortality after liver transplantation, supporting its use in pretransplant assessment and perioperative planning.