Pediatrics – Page 8

Early Childhood Exposure to Crohn’s Disease-Affected Siblings: Implications for Gut Microbiome and Disease Susceptibility

By MedXY 08/28/2026

Childhood exposure to siblings with Crohn's disease significantly raises disease risk, linked to distinct gut microbiome changes that may drive disease onset through immune modulation.

Hematology-Oncology news Pediatrics

Reassessing Total Body Irradiation in Young Children with ALL: Long-Term Safety and Outcomes

By MedXY 08/25/2026

A French longitudinal study finds no increased long-term complications or compromised quality of life in children under 4 years undergoing TBI-based HSCT for acute lymphoblastic leukemia, challenging prior age restrictions.

Neurology news Pediatrics

Early Escalation of Acute Treatment Reduces Relapse Risk in Pediatric MOG Antibody-Associated Disease

By MedXY 08/25/2026

In pediatric myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), escalation of acute immunotherapy beyond steroids at first attack is linked to significantly fewer relapses within one year and mid-term follow-up, highlighting a critical therapeutic window to alter disease trajectory.

Diabetes & Endocrinology news Pediatrics

Fecal Short-Chain Fatty Acids in Mother-Infant Dyads: No Direct Link to Islet Autoimmunity Development

By MedXY 08/25/2026

A longitudinal study shows no association between fecal short-chain fatty acid levels during pregnancy and early childhood with the progression to islet autoimmunity in children at risk for type 1 diabetes.

news Ophthalmology Pediatrics

Long-Term Outcomes of Strabismus Surgery in Children with Perinatal Brain Injury: Insights and Clinical Implications

By MedXY 08/24/2026

Children with perinatal brain injury exhibit lower long-term success rates following strabismus surgery, mainly due to undercorrection despite comparable surgical dosing. Larger preoperative deviations predict poorer outcomes, underscoring the need for tailored counseling and treatment strategies.

Clinical Updates Neurology news Pediatrics

Paternal Valproate Exposure and Offspring Neurodevelopmental Outcomes: A Comprehensive Review of Current Evidence

By MedXY 08/24/2026

This review synthesizes evidence on paternal valproate exposure and offspring neurodevelopmental risks, highlighting recent large cohort data that challenge prior concerns of increased neurodevelopmental disorders or congenital malformations.

news Otorhinolaryngology Pediatrics

Impact of Palate Repair Timing within First 15 Months on Early Speech Development in Children with Cleft Palate

By MedXY 08/21/2026

This study investigates how the timing of primary palate repair before 15 months influences early speech outcomes, finding that even slight delays increase the risk of passive cleft speech characteristics by age 36 months.

news Otorhinolaryngology Pediatrics

Expanding Pediatric Cochlear Implant Indications: Multicenter Evidence Supports Safety and Efficacy in Younger Children and Those with Residual Hearing

By MedXY 08/21/2026

A multicenter study demonstrates the safety and effectiveness of MED-EL cochlear implants in children under 12 months and in 12-71 month-olds with residual hearing, supporting expanded pediatric CI candidacy.

Diabetes & Endocrinology news Pediatrics

Circulating miR-1-3p Precedes Adrenarche and Modulates Adrenocortical Steroidogenesis via Protein Kinase C Signaling

By MedXY 08/21/2026

Circulating miR-1-3p levels rise before clinical signs of adrenarche and regulate adrenal steroid hormone production through protein kinase C signaling pathways.

Clinical Updates Dermatology news Pediatrics Respiratory

Early Respiratory Infection Burden and Atopic Dermatitis in Childhood: Insights from Prospective Birth Cohorts

By MedXY 08/20/2026

Emerging evidence from prospective birth cohorts reveals a dose-dependent association between early respiratory infections and the risk of childhood atopic dermatitis, independent of genetic predisposition and antibiotic exposure.

Infectious Diseases news Pediatrics

Rotavirus Vaccine Significantly Reduces Mortality from Rotavirus-Associated Acute Gastroenteritis in Children Under 5: Insights from the MNSSTER-V Global Dataset

By MedXY 08/20/2026

A pooled analysis from 22 countries demonstrates that rotavirus vaccination is highly effective in preventing rotavirus-positive acute gastroenteritis deaths in children under five, underscoring the vaccine's critical role in reducing childhood diarrheal mortality worldwide.

Emergency Medicine news Pediatrics

Impact of Emergency Department Pediatric Readiness and Inpatient Services on Child Mortality: A Decade-Long Cohort Study

By MedXY 08/20/2026

This cohort study links changes in emergency department pediatric readiness and inpatient pediatric services over ten years with excess child mortality, highlighting the critical role of hospital preparedness in pediatric survival.

Infectious Diseases news Pediatrics

Congenital Tuberculosis in a 2-Week-Old Neonate With an Asymptomatic Mother

By MedXY 08/20/2026

A 2-week-old neonate developed congenital tuberculosis despite an asymptomatic mother, illustrating diagnostic challenges and the need for heightened awareness of TB in pregnancy.

Diabetes & Endocrinology news Pediatrics

Steroids, Stress, and Body Mass Index Interact to Accelerate Female Pubertal Development

By MedXY 08/19/2026

Elevated glucocorticoids, androgens, and progesterone metabolites, combined with high BMI and stress, accelerate the onset of puberty in girls, particularly breast development (thelarche).

Cardiology news Pediatrics

Rigosertib: A Promising Therapeutic Agent for Reversing Hypertrophic Cardiomyopathy in Noonan Syndrome

By MedXY 08/19/2026

Rigosertib demonstrates significant reversal of hypertrophic cardiomyopathy and other syndromic features in Noonan syndrome models, highlighting its potential as a targeted therapy for RASopathy-associated cardiac and developmental abnormalities.

news Otorhinolaryngology Pediatrics

Rising Trends and Critical Insights into Pediatric Button Battery Ingestions: A Comparative Study from 2010 to 2025

By MedXY 08/18/2026

Pediatric button battery ingestions increased over 15 years, with larger batteries and more esophageal impactions. Delays in caregiver recognition drive prolonged exposure, contributing to serious complications. Public awareness is crucial to improve outcomes.

Cardiology news Pediatrics

HIF2 Activation in Cardiac Vasculature: A Novel Mechanistic Insight into Kawasaki Disease’s Cardiovascular Complications

By MedXY 08/18/2026

This study reveals how HIF2 activation drives coronary artery remodeling, inflammation, and thrombosis in a mouse model mirroring severe Kawasaki disease, uncovering new therapeutic targets for coronary complications.

Clinical Updates Neurology news Pediatrics

Neurological Effects and Safety of Encapsulated Dexamethasone Sodium Phosphate in Pediatric Ataxia Telangiectasia: Insights from the NEAT Phase 3 Trial

By MedXY 08/17/2026

The NEAT phase 3 trial evaluated erythrocyte-encapsulated dexamethasone sodium phosphate in children with ataxia telangiectasia aged 6–9 years, confirming safety but failing to demonstrate statistically significant neurological improvement over placebo.

Infectious Diseases news Pediatrics

Distinct Symptom Profiles and Outcomes of Respiratory Pathogens in Young US Children: Insights From a 2019-2025 Cohort Study

By MedXY 08/17/2026

This longitudinal study characterizes symptom variability and outcomes of respiratory infections among young children, revealing age-specific severity patterns and notable differences between influenza A and B.

news Ophthalmology Pediatrics

Neurodevelopmental Outcomes of Anti-VEGF versus Laser Photocoagulation for Retinopathy of Prematurity: Insights from a Comprehensive Review by the American Academy of Ophthalmology

By MedXY 08/17/2026

This review synthesizes current evidence on neurodevelopmental outcomes after treating retinopathy of prematurity with anti-VEGF injections versus laser photocoagulation, finding no significant differences in long-term cognitive or developmental effects.