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This extensive birth cohort study from Cincinnati, Ohio, spanning 2019 to 2025, provides a granular view of respiratory pathogen symptomatology and clinical outcomes in healthy infants and children. Key findings include increased respiratory distress with influenza A, RSV, human metapneumovirus, and SARS-CoV-2 among infants compared to older children; marked differences in symptom patterns between influenza A and B; high rates of asymptomatic infections; and notable gastrointestinal symptoms accompanying respiratory illnesses.
