HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Unraveling Transplant-Specific Mucosal Immune Dysfunction
Posted inInfectious Diseases news Oncology

HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Unraveling Transplant-Specific Mucosal Immune Dysfunction

Solid organ transplant recipients have increased risk of HPV-driven anal dysplasia and cancer due to unique immune alterations from immunosuppression. This article explores the transplant-specific immune dysfunction underlying persistent HPV infection and dysplastic progression, highlighting implications for screening and management.
Immunogenicity and Safety of Pentavalent Meningococcal MenABCWY Vaccine in Adolescents and Young Adults: Integrated Evidence from Late-Phase Clinical Trials
Posted inClinical Updates news Pediatrics Public Health

Immunogenicity and Safety of Pentavalent Meningococcal MenABCWY Vaccine in Adolescents and Young Adults: Integrated Evidence from Late-Phase Clinical Trials

This review synthesizes phase 2 and 3 trial data demonstrating that the pentavalent MenABCWY vaccine is immunologically non-inferior and well tolerated compared with MenB-fHbp and MenACWY-CRM vaccines, offering a simplified, effective vaccination strategy against invasive meningococcal disease in adolescents and young adults.
HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Exploring Transplant-Specific Mucosal Immune Dysregulation
Posted inInfectious Diseases news Oncology Transplantation

HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Exploring Transplant-Specific Mucosal Immune Dysregulation

Solid organ transplant recipients exhibit heightened risk for HPV-associated anal dysplasia and cancer due to unique immunosuppressive alterations. A transplant-tailored model of mucosal immune dysfunction elucidates mechanisms driving persistent HPV infection and dysplasia progression, informing future screening and therapeutic strategies.