Specialties – Page 9

Long-Term Comparative Outcomes of Bilateral versus Single Internal Thoracic Artery Grafts in Coronary Bypass Surgery

By MedXY 09/06/2026

This analysis of a randomized trial finds no survival benefit at 15 years for bilateral versus single internal thoracic artery grafting in coronary bypass surgery, highlighting the need for further trials to clarify the multiple arterial graft hypothesis.

Cardiology news

Harnessing Genetic Insights: Polygenic Risk Score Enhances Prediction of Peripheral Artery Disease and Limb Events

By MedXY 09/06/2026

A validated polygenic risk score (PRS) independently predicts peripheral artery disease (PAD) and major adverse limb events (MALE) in patients with cardiometabolic disease, adding modest but significant predictive value beyond traditional clinical risk factors.

Cardiology news

Validated Risk Stratification for RYR2-Mediated Catecholaminergic Polymorphic Ventricular Tachycardia on Beta-Blocker Therapy

By MedXY 09/06/2026

This article reviews a validated clinical risk model predicting arrhythmic events in patients with RYR2-mediated CPVT receiving beta-blockers, facilitating personalized management to reduce life-threatening arrhythmias.

Cardiology news

Stent Retriever Thrombectomy Reduces Infarct Size in High-Thrombus Myocardial Infarction: Insights from the NATURE Trial

By MedXY 09/06/2026

The NATURE trial demonstrates that stent retriever thrombectomy combined with conventional PCI significantly reduces infarct size in STEMI patients with large thrombus burden, without increasing short-term adverse events.

Cardiology news

Lepodisiran’s Impact on Oxidized Phospholipids in Lipoprotein(a): Advancing Cardiovascular Risk Reduction

By MedXY 09/06/2026

Lepodisiran, an siRNA targeting Lp(a), significantly reduces oxidized phospholipids on apo(a) and apoB, highlighting its therapeutic potential in lowering cardiovascular risk linked to elevated Lp(a).

Cardiology news

Advancing Familial Hypercholesterolemia Diagnosis: Activity-Normalized Prime Editing for Comprehensive LDLR Variant Classification

By MedXY 09/06/2026

A novel prime editing screening method enables precise functional classification of LDLR gene variants, enhancing diagnosis and therapeutic strategies for familial hypercholesterolemia.

Cardiology news

Targeting the CXCL9/CXCL10-CXCR3+ CD8+ T Cell Axis: Unraveling Anti-PD-1 Antibody-Associated Cardiotoxicity in Pressure Overload Heart Failure

By MedXY 09/06/2026

Anti-PD-1 antibody exacerbates pressure overload-induced heart failure by promoting CXCR3+ CD8+ T cell infiltration, which impairs cardiomyocyte mitochondrial function via granzyme B and perforin. This study identifies a novel immunopathogenic mechanism and therapeutic targets to mitigate cardiotoxicity.

$Bicistronic CD19/CD22 CAR T-Cell Therapy: A Breakthrough for Pediatric Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia$

Hematology-Oncology news Pediatrics

Bicistronic CD19/CD22 CAR T-Cell Therapy: A Breakthrough for Pediatric Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

By MedXY 09/06/2026

A phase 2 trial shows bicistronic CD19/CD22 CAR T-cell therapy yields high remission rates with durable event-free survival in pediatric relapsed/refractory B-ALL, reducing antigen-negative relapse risks and improving outcomes.

news Ophthalmology

Prevalence and Characteristics of Null Studies in Ophthalmology: A Comprehensive Analysis from 2014 to 2025

By MedXY 09/05/2026

A large-scale PubMed analysis reveals that one in five ophthalmology studies report null primary outcomes, with declining prevalence over time and notable differences in funding, design, and journal impact between null and positive studies.

Neurology news Otorhinolaryngology

Prednisone Use Post-Acoustic Neuroma Surgery Does Not Prevent Delayed Facial Nerve Palsy: A Retrospective Analysis

By MedXY 09/05/2026

A retrospective study found that postoperative prednisone tapering does not reduce delayed facial nerve palsy incidence following acoustic neuroma resection and carries a 10% risk of steroid-related side effects.

news Otorhinolaryngology

Tailoring Surgical Tools: The Differential Impact of 3D-Printed Temporal Bone Models on Cognitive Load in Cochlear Implantation

By MedXY 09/05/2026

This randomized controlled trial evaluates how patient-specific 3D-printed temporal bone models influence surgeon cognitive load during cochlear implantation, revealing experience-dependent benefits for attendings and challenges for trainees.

General Surgery news Oncology

Refining Prognostic Stratification in Hepatocellular Carcinoma: The Critical Role of Vascular Invasion Type and Extent

By MedXY 09/05/2026

This study elucidates how distinct patterns and gradations of vascular invasion in hepatocellular carcinoma differentially impact recurrence timing and overall survival, enabling improved postoperative risk stratification.

Diabetes & Endocrinology General Surgery news

Predicting Hypothyroidism After Hemithyroidectomy: Development and Validation of a Clinical Nomogram for Personalized Risk Assessment

By MedXY 09/05/2026

A validated nomogram predicts hypothyroidism risk within 12 months after hemithyroidectomy using clinical and pathological variables, aiding tailored patient counseling and postoperative monitoring.

General Surgery news Oncology

Unveiling the Molecular Evolution from Primary Gastric Cancer to Peritoneal Metastases: Implications for Targeted Surgical Oncology

By MedXY 09/05/2026

This study elucidates transcriptomic differences between primary gastric cancers and peritoneal metastases, revealing distinct tumor microenvironments and molecular pathways, highlighting potential targets for improved diagnosis and therapy in advanced gastric cancer.

Clinical Updates General Surgery news

Negative Pressure Therapy in Major Lower Extremity Amputation: A Critical Review of Current Randomized Controlled Trials

By MedXY 09/05/2026

This review synthesizes evidence from recent randomized controlled trials assessing negative pressure therapy (NPT) for reducing wound complications after major lower extremity amputation, highlighting variable efficacy and potential benefit in selected high-risk subgroups.

news OB/GYN & Women's Health

Maternal Supine Sleep in Late Pregnancy: No Impact on Fetal Growth in Prospective Cohort Study

By MedXY 09/05/2026

This study finds no association between objectively measured maternal supine sleep during late pregnancy and customised birthweight centiles, suggesting mechanisms other than fetal growth underlie the risk of stillbirth with supine sleep position.

news OB/GYN & Women's Health

Fetal Growth Restriction and Risk of Superimposed Preeclampsia in Women with Chronic Hypertension: Implications for Clinical Surveillance

By MedXY 09/05/2026

In women with chronic hypertension, fetal growth restriction at 35-36 weeks gestation predicts higher progression to superimposed preeclampsia, underscoring the need for targeted maternal-fetal surveillance.

Infectious Diseases news OB/GYN & Women's Health

Intra-amniotic Categories of Preterm Prelabor Rupture of Membranes: Gestational Age-Specific Distribution, Amniotic Fluid Microbial Profiles, and Neonatal Outcomes

By MedXY 09/05/2026

This study classifies preterm prelabor rupture of membranes (PROM) into four intra-amniotic types, detailing differences in gestational age distribution, microbial profiles, and neonatal outcomes, highlighting risks associated with infections beyond Ureaplasma spp.

news OB/GYN & Women's Health

Enhancing Sexual and Pelvic Health in Women: Efficacy of Scheduled Vibrator Use in a Randomized Controlled Trial

By MedXY 09/05/2026

Scheduled vibrator use combined with educational support significantly improves sexual function in women with sexual dysfunction and pelvic floor disorders compared to education alone.

news OB/GYN & Women's Health Public Health

Updated Federal Regulation: How the Pregnant Workers Fairness Act (PWFA) Changes Care and Counseling in Obstetrics

By MedXY 09/05/2026

This article summarizes ACOG’s 2026 Committee Statement on the Pregnant Workers Fairness Act, explains clinician roles in documentation and accommodation, and outlines practical recommendations for obstetric care.