Diabetes & Endocrinology – Page 3

Adolescent MASLD Plus PCOS Signals a Higher-Risk Cardiometabolic Trajectory Into Adulthood

By MedXY 05/28/2026

In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Automated Insulin Delivery Improves Glycemia During Labor and Early Postpartum in Type 1 Diabetes: Clinical Insights From the CIRCUIT Trial

By MedXY 05/28/2026

A prespecified CIRCUIT analysis found that Control-IQ closed-loop insulin delivery improved intrapartum time in range and reduced early postpartum hypoglycemia versus standard care in women with type 1 diabetes, without new safety concerns.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Prepregnancy Insulin Resistance and Fertility Outcomes in Women With PCOS

By MedXY 05/26/2026

Higher insulin resistance before pregnancy was linked to poorer ovulation, lower pregnancy and live-birth rates, and more gestational diabetes in women with PCOS. Improving insulin resistance during treatment was associated with better pregnancy outcomes.

Diabetes & Endocrinology Family Medicine & Nutrition news

Can Long-Term Thyroid Cancer Follow-Up Safely Move to Primary Care? Prospective Data Support De-Escalation After Excellent Response

By MedXY 05/26/2026

A prospective cohort study suggests that differentiated thyroid cancer patients with sustained excellent response after at least 5 years of specialist follow-up can be safely transitioned to primary care with very low recurrence risk.

Diabetes & Endocrinology Gastroenterology news

Duodenal Recombinant RORDEP1 Was Safe and Triggered Early Incretin-Insulin Responses in Healthy Men

By MedXY 05/26/2026

In a randomized crossover trial, short-term duodenal r-RORDEP1 infusion was well tolerated and produced early changes in GLP-1, GIP, insulin, C-peptide, glucose, and a measure of insulin sensitivity in healthy men.

Diabetes & Endocrinology Hematology-Oncology news

Safety and Effectiveness of Rivaroxaban Thromboprophylaxis in ACTH-Dependent Cushing Syndrome

By MedXY 05/26/2026

Routine oral rivaroxaban prophylaxis in ACTH-dependent Cushing syndrome was associated with no new VTE events after implementation and no bleeding complications, suggesting it is a safe and effective preventive strategy.

Diabetes & Endocrinology news Psychiatry

Semaglutide Improves Insulin Sensitivity in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial

By MedXY 05/26/2026

In a 30-week randomized trial, semaglutide improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and produced substantial weight loss in patients with schizophrenia and prediabetes taking second-generation antipsychotics.

Diabetes & Endocrinology news

Six-Week Native GIP Infusion Does Not Improve Glycaemic Control in Type 2 Diabetes, Alone or With Semaglutide

By MedXY 05/26/2026

A six-week native GIP infusion did not improve glucose control in type 2 diabetes, either alone or added to semaglutide, despite raising circulating GIP levels.

Cardiology Diabetes & Endocrinology news

Oral Semaglutide and Cardiovascular Risk Factor Changes in High-Risk Type 2 Diabetes

By MedXY 05/26/2026

Oral semaglutide improved multiple cardiovascular risk factors in high-risk type 2 diabetes, including HbA1c, weight, systolic blood pressure, inflammation, and some lipid measures, with benefits sustained over nearly four years.

Clinical Updates Diabetes & Endocrinology news

Synergistic Protection of Pancreatic Beta Cells: GLP1-E2 and Low-Dose Anti-CD3 Combination Therapy in Autoimmune Diabetes

By MedXY 05/20/2026

Recent studies demonstrate that combining the beta-cell-targeted conjugate GLP1-E2 with low-dose anti-CD3 therapy significantly delays type 1 diabetes onset by simultaneously reducing immune infiltration and mitigating beta-cell cellular stress.

Diabetes & Endocrinology news Pediatrics

Children Born SGA Receiving Growth Hormone Have Similarly Impaired Glucose-Insulin Metabolism as Children With Obesity

By MedXY 05/19/2026

Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.

Diabetes & Endocrinology news Public Health

A U-Shaped Association Between Blood mtDNA Copy Number and Risk of Type 2 Diabetes

By MedXY 05/19/2026

Blood mtDNA copy number showed a U-shaped association with future type 2 diabetes risk in younger adults, suggesting that both low and high levels may signal higher risk.

Allergy & Immunology Diabetes & Endocrinology news

Immune-Cell Transcriptomics and Mendelian Randomisation Identify New Causal Genes for Type 2 Diabetes Complications

By MedXY 05/16/2026

This study used immune-cell gene expression and genetic analyses to identify causal genes and immune pathways linked to type 2 diabetes and its complications, highlighting diabetic neuropathy as a distinct cluster and prioritising ten promising drug targets.

Cardiology Diabetes & Endocrinology news

Retatrutide Produces Broad Favorable Shifts in Fatty Acid Oxidation and Insulin Resistance Biomarkers in Obesity With or Without Type 2 Diabetes

By MedXY 05/16/2026

Post-hoc metabolomic and lipidomic analyses from two phase 2 trials suggest retatrutide favorably remodels metabolic pathways linked to fatty acid oxidation, insulin resistance, and triglyceride composition in obesity, with and without type 2 diabetes.

Diabetes & Endocrinology news Public Health

Improving the Algorithm: Adding a Socioeconomic Measure to Predict Type 2 Diabetes in Youth With Prediabetes

By MedXY 05/16/2026

Adding the Area Deprivation Index to HbA1c improved prediction of type 2 diabetes within 1 year in youth with prediabetes, highlighting the importance of socioeconomic factors in diabetes risk.

Diabetes & Endocrinology news

Preventing Severe Hypoglycemia in Type 2 Diabetes: Randomized Trial of Proactive Care With or Without Psychoeducation

By MedXY 05/15/2026

A randomized trial in high-risk adults with type 2 diabetes found that proactive nurse-led care reduced severe hypoglycemia by about 50%, while adding psychoeducation did not significantly improve outcomes further.

Diabetes & Endocrinology news Ophthalmology

Tocilizumab Shows Promising Benefits in Glucocorticoid-Resistant Thyroid Eye Disease

By MedXY 05/13/2026

In two prospective cohorts of active, glucocorticoid-resistant thyroid eye disease, tocilizumab improved eye inflammation, proptosis, diplopia, and quality of life with acceptable safety, supporting IL-6 blockade as a promising second-line treatment.

Diabetes & Endocrinology news Public Health

Staging Intermediate Hyperglycaemia to Improve Type 2 Diabetes Prevention: Findings from the ELSA-Brasil Study

By MedXY 05/13/2026

The ELSA-Brasil study found that staging intermediate hyperglycaemia with fasting glucose plus 1-hour glucose better predicted type 2 diabetes than fasting glucose plus HbA1c, and a clinical risk score reduced unnecessary testing.

Diabetes & Endocrinology news Oncology

Most Bilateral Adrenal Lesions Are Benign and Concordant, but Asynchronous Presentation Signals Higher Malignancy Risk

By MedXY 05/13/2026

A large retrospective cohort shows that bilateral adrenal masses are usually benign and concordant, but asynchronous or discordant lesions identify a clinically important subgroup enriched for malignancy and pheochromocytoma.

Diabetes & Endocrinology news Public Health

Weight Regain Can Reverse the Metabolic Benefits of Caloric Restriction: Insights From CALERIE-2

By MedXY 05/13/2026

CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.