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- Detectable stimulated C-peptide (>0.2 nmol/mL) reflects endogenous insulin production in type 1 diabetes.
- Residual C-peptide is strongly associated with a markedly reduced risk of diabetic ketoacidosis (DKA).
- Over 99% of DKA episodes occurred when C-peptide levels were low or undetectable.
- Preserving beta-cell function may offer a critical therapeutic target to mitigate DKA risk long term.
