Cardiology – Page 10

Decoding the Heart Failure Peptidome: A Cross-Sectional Study Uncovers Novel Biomarkers and Patient Clusters

By MedXY 04/05/2026

A groundbreaking mass spectrometry study analyzing 486 heart failure patients and 98 controls identified over 21,000 unique peptides, revealing 1,924 differentially expressed peptides. The research highlights angiotensin-related peptides, natriuretic peptide pathways, and cardiometabolic regulators as key outcome predictors, while identifying three distinct patient clusters with varying survival probabilities.

Cardiology news

Only 1 in 5 Veterans with Heart Failure Achieve Recommended Quadruple Therapy Within 3 Years—What This Means for Clinical Practice

By MedXY 04/05/2026

A large retrospective study of 52,850 veterans reveals that just 21.2% achieve guideline-directed quadruple therapy for HFrEF, with a median time of 197 days. Socioeconomic barriers, including prescription copays, emerge as critical modifiable factors hindering optimal treatment uptake.

Cardiology news

Pulsed Field Ablation Matches Radiofrequency in Efficacy but Shows Superior Safety Profile for Paroxysmal Atrial Fibrillation: BEAT PAROX-AF Trial

By MedXY 04/05/2026

The BEAT PAROX-AF trial demonstrates equivalent single-procedure success rates between pulsed field ablation (77.2%) and radiofrequency ablation (77.6%) for paroxysmal atrial fibrillation, while showing a numerically lower safety event rate with PFA (3.4% vs 7.6%).

Cardiology Clinical Updates news

Redefining the Renin-Aldosterone Axis: From Categorical Diagnosis to a Continuous Spectrum of Cardiorenal Risk

By MedXY 04/05/2026

This article synthesizes evidence from a 2026 Danish nationwide cohort and supporting literature, illustrating that renin-independent aldosterone production represents a continuous risk gradient for kidney failure and MACE, even below traditional diagnostic thresholds for primary aldosteronism.

AI Cardiology news

Adaptive AI Transforms Cardiovascular Event Adjudication: New Algorithm Achieves Near-Human Accuracy Across Multiple Endpoints

By MedXY 04/05/2026

Researchers developed and validated ADAPT-CEC, an artificial intelligence algorithm that can adjudicate cardiovascular events across different trial definitions. A hybrid approach combining AI with selective human review achieved 95.6% accuracy and replicated major trial results.

Cardiology General Surgery news

Volume Matters: New Study Defines Minimum Annual Caseload for Safer Fenestrated and Branched Aortic Repair

By MedXY 04/02/2026

Researchers identify critical hospital and surgeon volume thresholds for fenestrated/branched endovascular aortic repair (F/BEVAR). Patients treated at low-volume centers face up to 51% higher 30-day mortality, with inflection points at 9 hospital cases and 7 surgeon cases annually.

Cardiology Clinical Updates Diabetes & Endocrinology news

Precision Phenotyping in Cardiometabolic Medicine: Genetic Susceptibility of Diabetes Subtypes and Coronary Artery Disease Risk

By MedXY 04/01/2026

This review synthesizes evidence on the genetic architecture of adult-onset diabetes subtypes, highlighting that Moderate Obesity-related Diabetes (MOD) is uniquely and causally linked to coronary artery disease risk through polygenic and Mendelian randomization analyses.

Cardiology Diabetes & Endocrinology news

STEMI and NSTEMI Are Not the Same in Type 1 Diabetes: Finnish Cohort Reveals Distinct Risk Patterns

By MedXY 04/01/2026

In Finnish adults with type 1 diabetes, STEMI and NSTEMI showed distinct incidence trends and risk profiles. NSTEMI was more common overall and linked to dyslipidemia and advanced microvascular disease, whereas impaired eGFR tracked more with STEMI.

Cardiology Clinical Updates Diabetes & Endocrinology news

Long-Term Durability and Clinical Stability of Acoramidis in Transthyretin Amyloid Cardiomyopathy: A 54-Month Synthesis

By MedXY 04/01/2026

This review synthesizes the 54-month results of the ATTRibute-CM open-label extension, demonstrating that early and continuous acoramidis treatment provides sustained reductions in mortality and cardiovascular hospitalizations while maintaining functional capacity and biomarker stability in ATTR-CM patients.

Cardiology Internal Medicine news

Cardiologist Evaluation After Postoperative Myocardial Injury Was Linked to Better 1-Year Outcomes

By MedXY 04/01/2026

Post-operative cardiologist evaluation after peri-operative myocardial injury was associated with fewer major cardiac events and lower 1-year mortality in high-risk non-cardiac surgery patients.

Cardiology Clinical Updates news

Optimizing Post-Operative Outcomes: The Critical Impact of Specialist Cardiology Evaluation in Peri-operative Myocardial Infarction and Injury

By MedXY 04/01/2026

This review analyzes evidence demonstrating that cardiologist evaluation for peri-operative myocardial infarction/injury (PMI) significantly reduces 1-year major adverse cardiac events and all-cause mortality through optimized diagnostic and therapeutic interventions.

Cardiology news

IVUS Guidance Slashes 1-Year Target Vessel Failure in Complex Bifurcation PCI: Insights from DKCRUSH VIII

By MedXY 03/31/2026

The DKCRUSH VIII trial demonstrates that IVUS-guided PCI for complex coronary bifurcation lesions significantly reduces 1-year target vessel failure compared to angiography guidance, primarily by ensuring adherence to specific optimization criteria during the double kissing crush technique.

Cardiology Clinical Updates Diabetes & Endocrinology news

Mid-Regional Pro-Adrenomedullin (MR-proADM): A Superior Prognostic Sentinel in Transthyretin Cardiac Amyloidosis

By MedXY 03/31/2026

This review synthesizes recent evidence identifying MR-proADM as a premier prognostic biomarker in ATTR-CM, demonstrating its ability to outperform traditional natriuretic peptides and enhance existing clinical staging systems.

Cardiology Gastroenterology news

Beyond the Backpressure: Targeting the Integrin αV-YAP-CTGF Axis to Halt Fibrosis in Congestive Hepatopathy

By MedXY 03/31/2026

This study identifies the integrin αV-YAP-CTGF axis in liver sinusoidal endothelial cells as a primary driver of fibrosis and carcinogenesis in congestive hepatopathy. By targeting this mechanosensitive pathway, researchers demonstrated a significant reduction in portal hypertension and liver damage in both murine models and human clinical samples.

Cardiology Clinical Updates news

Advancing Venous Thromboembolism Prediction: Insights from Large-Scale Plasma Proteomics and Mendelian Randomization

By MedXY 03/31/2026

This review synthesizes findings from a landmark proteomic study identifying 23 plasma proteins associated with VTE risk, highlighting novel pathways in immunity and vascular senescence while exploring causal links through Mendelian Randomization.

Cardiology Hematology-Oncology news

Beyond the Clot: Novel Proteomic Markers Reveal New Pathophysiological Pathways for Venous Thromboembolism

By MedXY 03/31/2026

A large-scale proteomic meta-analysis across five cohorts identified 15 novel plasma protein markers for venous thromboembolism, highlighting the roles of the extracellular matrix, immunity, and vascular senescence in disease risk and offering potential new targets for clinical prevention.

Cardiology news

Synergistic Risk Assessment: Coronary Artery Calcium Scoring Remains Vital in Patients with Elevated Lipoprotein(a)

By MedXY 03/30/2026

A large-scale multicohort study demonstrates that while elevated Lipoprotein(a) increases cardiovascular risk, Coronary Artery Calcium (CAC) scoring remains a powerful independent predictor of events, even in patients with high Lp(a) levels, providing essential clarity for clinical risk stratification.

Cardiology Clinical Updates Internal Medicine news

Deciphering the Clinician’s Dilemma: Determinants of Antihypertensive Treatment Intensification in Older Adults

By MedXY 03/28/2026

This review analyzes the complex factors influencing blood pressure management in older adults, highlighting how age, frailty, and digital health data shape clinician decisions and clinical inertia.

Cardiology Gastroenterology news

Targeting the Integrin αV-YAP-CTGF Axis: A New Frontier in Treating Congestive Hepatopathy and Liver Carcinogenesis

By MedXY 03/28/2026

Researchers have identified a mechanosensitive signaling pathway in liver sinusoidal endothelial cells that drives fibrosis and cancer in response to chronic congestion, offering a new therapeutic target for heart-failure-related liver disease.

Cardiology Gastroenterology news

From Pressure to Cancer: Unveiling the Integrin αV-YAP-CTGF Axis as a Therapeutic Target in Congestive Hepatopathy

By MedXY 03/28/2026

Researchers have identified a novel signaling pathway in liver sinusoidal endothelial cells (LSECs) that drives fibrosis and liver cancer in congestive hepatopathy. The study highlights the Integrin αV-YAP-CTGF axis as a critical mechanism and potential therapeutic target for patients with chronic hepatic congestion.