A recently validated polygenic risk score (PRS) is independently associated with prevalent peripheral artery disease (PAD) and incidence of major adverse limb events (MALE) in cardiometabolic patients.
Each standard deviation increase in PRS confers a 15% higher odds of prevalent PAD and a 30% increased risk of MALE, comparable to established clinical risk factors.
Incorporating the PAD PRS with clinical variables modestly improves risk discrimination for MALE but may have limited immediate clinical utility.
