acute kidney injury

H3.1 Nucleosomes as Predictive Biomarkers for Renal Replacement Therapy and Mortality in Sepsis: Insights from the SISPCT Trial

By MedXY 08/07/2026

Elevated plasma levels of H3.1 nucleosomes at ICU admission correlate with increased mortality and acute kidney injury requiring renal replacement therapy in sepsis, highlighting their potential as prognostic biomarkers.

Critical Care Nephrology news

Evaluating Renal Resistive Index Responsiveness to MAP Targets in Early Septic Shock: Clinical Implications and Physiologic Insights

By MedXY 08/05/2026

This study explores whether renal resistive index (RRI) changes during a transient elevation of mean arterial pressure (MAP) can guide individualized MAP targets to optimize renal function in early septic shock, finding that RRI decrease does not predict improved outcomes with higher MAP, while lack of RRI decrease may identify patients benefiting from MAP elevation.

Nephrology Neurology news

Balancing Blood Pressure After Endovascular Thrombectomy: Risks of Acute Kidney Injury and Impact on Stroke Recovery

By MedXY 07/31/2026

Intensive blood pressure lowering post-thrombectomy increases acute kidney injury risk, which correlates with poorer neurological outcomes in stroke patients. Careful BP management is crucial to prevent renal complications and optimize recovery.

Anesthesiology Critical Care news

Optimizing Intraoperative Blood Pressure in Hypertensive High-Risk Patients: Insights from the HISTAP Trial

By MedXY 07/09/2026

In hypertensive high-risk patients undergoing major abdominal surgery, targeting an intraoperative mean arterial pressure ≥80 mmHg reduces postoperative organ dysfunction and acute kidney injury compared to the standard target of ≥65 mmHg.

Gastroenterology Nephrology news

Chronic Kidney Disease Worsens Short-Term Outcomes in Hospitalized Patients With Cirrhosis Across a Global Cohort

By MedXY 06/07/2026

In a large international prospective cohort of hospitalized patients with cirrhosis, chronic kidney disease was common, clustered with metabolic risk, and strongly associated with acute kidney injury, more decompensation, and higher in-hospital and 30-day mortality.

Gastroenterology Nephrology news

OCE-205 Signals a Potential New Direction for Hepatorenal Syndrome-AKI, with Tolerability at the Center

By MedXY 04/20/2026

In a phase 2 randomized trial, OCE-205 improved HRS-AKI in more patients than placebo and showed no excess ischemic or respiratory toxicity, but the study was underpowered after early termination.

Cardiology Critical Care news

Etiology, Management, and Outcomes of Society for Cardiovascular Angiography and Interventions Stage B Cardiogenic Shock

By MedXY 03/10/2026

This clinical analysis of 500 patients identifies heart failure and arrhythmias as the primary causes of SCAI Stage B shock. Key findings highlight acute kidney injury and diuretic resistance as significant predictors of clinical deterioration and the need for escalation of care.

Cardiology Critical Care news

The Warning Signs of Deterioration: Acute Kidney Injury and Diuretic Resistance in SCAI Stage B Cardiogenic Shock

By MedXY 03/01/2026

A large-scale study reveals that 25% of patients with SCAI Stage B cardiogenic shock deteriorate clinically. Acute kidney injury and diuretic resistance are identified as critical, independent predictors of poor outcomes, emphasizing the need for early intervention in 'beginning' shock.

Cardiology Critical Care news

AKI and Diuretic Resistance: Identifying the High-Risk Phenotype in SCAI Stage B Cardiogenic Shock

By MedXY 03/01/2026

New research highlights that nearly a quarter of SCAI Stage B cardiogenic shock patients deteriorate. Acute kidney injury and diuretic resistance serve as critical early warning signs, providing clinicians a window for proactive intervention before hemodynamic collapse.

Critical Care Nephrology news

Liberating the Kidney: Can a Conservative Dialysis Strategy Improve Recovery in AKI-D?

By MedXY 02/09/2026

The LIBERATE-D randomized trial suggests that a conservative, indication-driven dialysis strategy may enhance kidney recovery and reduce treatment burden in stable patients with dialysis-requiring acute kidney injury compared to conventional thrice-weekly dialysis.

Critical Care Nephrology news

Severe Acute Kidney Injury Survivors in India and Southeast Asia Face Staggering Rates of Long-Term Adverse Events

By MedXY 12/31/2025

A large-scale multicenter study reveals that 46.6% of severe AKI survivors in India and Southeast Asia experience major adverse kidney events (MAKE) within two years, with mortality and new-onset chronic kidney disease being the primary drivers.

Critical Care Nephrology news

Hospital Acute Kidney Injury Strongly Linked to Long-Term Death, Dialysis, and CKD: Meta-Analysis of Matched-Control Studies

By MedXY 12/09/2025

A meta-analysis of 14 matched-control studies (n=1,058,109) finds that survivors of in-hospital AKI face higher long-term mortality, greater subsequent dialysis need, and elevated risk of CKD versus matched controls.

Critical Care Nephrology news

Biomarker-Guided Preventive Care Halves Risk of Moderate–Severe AKI After Major Surgery: Results from BigpAK-2

By MedXY 11/26/2025

In BigpAK-2, a multinational randomized trial, a KDIGO-based preventive bundle triggered by tubular stress biomarkers reduced moderate or severe acute kidney injury within 72 hours after major surgery (OR 0.57; NNT 12) without increasing adverse events.

Nephrology news Pediatrics

Acute Kidney Injury in Extremely Preterm Infants Predicts Higher Risk of Death or Neurodevelopmental Impairment at Two Years

By MedXY 11/19/2025

Secondary analysis of the PENUT trial found that acute kidney injury (AKI) in infants born at 24–27 weeks’ gestation is independently associated with death or moderate to severe neurodevelopmental impairment at 22–26 months' corrected age.

Critical Care Nephrology news

Conservative Dialysis Strategy Accelerates Kidney Recovery in Dialysis-Requiring AKI — Early Randomized Evidence from LIBERATE-D

By MedXY 11/08/2025

The LIBERATE-D randomized trial found that a conservative, indication-triggered dialysis strategy increased unadjusted kidney-recovery rates at hospital discharge and shortened time to dialysis independence compared with routine thrice-weekly dialysis in patients with dialysis-requiring AKI.

Nephrology news

A‑E‑I‑O‑U and Sometimes Why—Dialysis in Acute Kidney Injury

By MedXY 11/08/2025

LIBERATE‑D randomized hemodynamically stable patients with AKI to conservative vs conventional thrice‑weekly continuation of KRT; conservative discontinuation increased dialysis‑free recovery, shortened time to recovery, and reduced sessions without detectable harm, challenging automatic thrice‑weekly schedules.

Critical Care Nephrology news

Sodium Bicarbonate in Severe Metabolic Acidemia with AKI: No Survival Benefit but Less Dialysis — Insights from BICARICU-2

By MedXY 11/07/2025

The BICARICU-2 randomized trial found that intravenous sodium bicarbonate in patients with severe metabolic acidemia and moderate-to-severe acute kidney injury did not reduce 90‑day mortality, but was associated with a substantial reduction in use of kidney replacement therapy.

Critical Care Nephrology news

Choice of Vasopressor in Septic Shock: Does It Change Kidney Outcomes? A Critical Appraisal of the Evidence

By MedXY 11/07/2025

A systematic review of 17 randomized trials (n=4,259) found no consistent renoprotective effect from any vasopressor in septic shock. Heterogeneous definitions, underpowered studies, and reliance on RRT limit conclusions; standardized renal endpoints and focused trials are needed.

Anesthesiology Cardiology General Surgery news

Pathogen-Reduced Red Blood Cells Are Safe in Cardiac Surgery: ReCePI Phase 3 Shows Noninferior AKI Rates

By MedXY 11/05/2025

The ReCePI randomized phase 3 trial found that amustaline/glutathione pathogen-reduced red blood cells produced similar rates of acute kidney injury compared with conventional transfusion after cardiac or thoracic-aorta surgery, with few treatment-emergent antibodies and no clinically significant hemolysis.

Anesthesiology Critical Care news

Individualized Perioperative Blood Pressure Management in Major Abdominal Surgery: Insights from the IMPROVE-multi Trial

By MedXY 10/13/2025

The IMPROVE-multi randomized clinical trial found that tailoring perioperative blood pressure targets to individual preoperative nighttime MAP levels did not reduce postoperative organ injury or mortality compared to routine management in high-risk major abdominal surgery patients.