MedXY – Page 16

Understanding Physicians’ Mental Models on Goals of Care in Chronic Critical Illness: Implications for Shared Decision Making

By MedXY 09/12/2026

This study explores how intensivists conceptualize appropriate goals of care and the influences of health system factors on decision-making for patients with chronic critical illness, emphasizing predictions about quality of life and functional outcomes.

Allergy & Immunology news Respiratory

Tezepelumab Demonstrates Robust Efficacy and Safety Across Diverse Severe Asthma Phenotypes: Insights from the Phase 4 PASSAGE Study

By MedXY 09/12/2026

The PASSAGE phase 4 study reveals tezepelumab significantly reduces exacerbation rates and improves lung function and quality of life in a broad US severe asthma population, including underrepresented groups and varied phenotypes.

news Respiratory

Efficacy of Dupilumab in Reducing COPD Exacerbations, Emergency Department Visits, and Corticosteroid Use: Insights from a Pooled Phase 3 Analysis

By MedXY 09/12/2026

Dupilumab significantly reduces emergency visits, hospital admissions, and systemic corticosteroid use in COPD patients with type 2 inflammation, offering a promising therapeutic option to mitigate exacerbation-associated morbidity.

news Ophthalmology

Differential Impact of Reticular Pseudodrusen Subtypes on Retinal Sensitivity in Intermediate Age-Related Macular Degeneration

By MedXY 09/12/2026

This study elucidates how ribbon-type reticular pseudodrusen, especially when coexisting with soft drusen, significantly impair retinal sensitivity in intermediate AMD, highlighting the importance of lesion phenotype in functional risk assessment.

Dermatology news Ophthalmology

Unveiling Dupilumab-Associated Ocular Surface Disease in Atopic Dermatitis: Insights from a Large Prospective BioDay Cohort

By MedXY 09/12/2026

This study reveals that 30.7% of atopic dermatitis patients treated with dupilumab develop ocular surface disease, despite prevalent ocular symptoms at baseline and increased ophthalmic treatment during therapy, linked to reduced conjunctival mucin production.

Diabetes & Endocrinology news Ophthalmology

Satralizumab Demonstrates Promising Efficacy and Safety in Treating Thyroid Eye Disease: Insights from Phase 3 SatraGO-1 and SatraGO-2 Trials

By MedXY 09/12/2026

Phase 3 trials show satralizumab significantly improves proptosis, inflammation, and diplopia in thyroid eye disease with a favorable safety profile, marking a new therapeutic option targeting the IL-6 receptor pathway.

news Otorhinolaryngology Respiratory

Prevalence of Voice Fatigue and Its Correlation With Xerostomia in E-Cigarette Smokers

By MedXY 09/12/2026

This study explores the high prevalence of voice fatigue among e-cigarette users and its significant correlation with dry mouth (xerostomia).

news Otorhinolaryngology Pediatrics

Long-Term Outcomes and Quality of Life in Children Following Nasal Button Battery and Magnet Removal

By MedXY 09/12/2026

This study evaluates the long-term sinonasal health and quality of life in children after removal of button batteries or magnets from the nose, highlighting favorable outcomes with prompt intervention and need for extended monitoring in symptomatic cases.

Gastroenterology General Surgery news

Evaluating Early Outcomes of Robotic versus Laparoscopic and Open Cholecystectomy in the US: A Nationwide Analysis

By MedXY 09/12/2026

A national multipayer analysis demonstrates robotic cholecystectomy offers comparable safety to laparoscopic methods while improving key outcomes versus open surgery, signaling maturation of robotic biliary surgery.

Emergency Medicine news Psychiatry

Predicting PTSD in Gunshot Wound Survivors: The Role of Shock Index, Hypotension, and Blood Transfusion

By MedXY 09/12/2026

This study highlights how early physiologic markers like shock index and hypotension can predict PTSD risk in gunshot wound survivors, while blood transfusion shows an inverse relationship, aiding targeted mental health interventions.

General Surgery news Oncology

Impact of Severe Anastomotic Leak After Esophagectomy on Long-Term Survival: Insights from a Modern Multicenter Cohort

By MedXY 09/11/2026

A large European study shows that severe anastomotic leaks requiring surgical reintervention after esophagectomy significantly reduce long-term survival and increase postoperative mortality, underscoring the need for targeted management strategies.

Gastroenterology General Surgery news

Global Hospital Infrastructure and Its Impact on Mortality After Pancreas Surgery: Insights from the Hospital Resource Index

By MedXY 09/11/2026

A global study identifies key hospital-level modifiable resources that reduce 90-day mortality after pancreas surgery and introduces a composite Hospital Resource Index to guide improvements beyond surgical volume centralization.

news OB/GYN & Women's Health Oncology

Impact of Mutated p53 on Type I Interferon Pathway Expression in Endometrial Cancer: Immune Modulatory Insights

By MedXY 09/11/2026

This study reveals distinct alterations in the type I interferon pathway expression and signaling linked to mutated p53 subtypes in endometrial cancer, highlighting differing immune microenvironments that impact prognosis and therapeutic considerations.

news OB/GYN & Women's Health Oncology

Minimally Invasive Radical Hysterectomy Without Uterine Manipulator vs Open Surgery for Early-Stage Cervical Cancer: Comparative Outcomes from a Large Propensity-Matched Cohort

By MedXY 09/11/2026

This retrospective study compares oncologic and perioperative outcomes of minimally invasive radical hysterectomy without uterine manipulator versus open radical hysterectomy in early-stage cervical cancer, showing comparable survival but improved perioperative recovery with MIS.

news OB/GYN & Women's Health Pathology & Lab Medicine

Advancing Fetal Death Detection: Identification of Novel Maternal Plasma Biomarkers Through Large-Scale Proteomic Profiling

By MedXY 09/11/2026

Large-scale proteomic analysis identifies novel maternal plasma protein biomarkers that improve detection of fetal death beyond established markers, highlighting both shared and unique pathological pathways with preeclampsia.

Clinical Updates news

Incidence, Survival, and Symptomatology of Recurrence in Vulvar Cancer: Insights from Population-Based Cohort Studies and Contemporary Evidence

By MedXY 09/11/2026

Vulvar cancer exhibits significant recurrence rates, predominantly local, with survival declining sharply after recurrence. Awareness of recurrence-associated symptoms enhances early detection. Surgery remains pivotal in management, with frailty and tumor characteristics influencing prognosis.

Gastroenterology news

Unveiling Excessive Supragastric Belching in Conclusive GERD: Clinical Insights and Predictors

By MedXY 09/11/2026

Excessive supragastric belching (SGB) occurs in nearly 20% of patients with conclusive gastro-oesophageal reflux disease, contributing significantly to acid exposure time and symptom burden. This multicentre study identifies clinical predictors and characterizes this SGB-related GERD phenotype.

Cardiology Neurology news

Global Trends in the Burden of Ischemic Stroke Attributable to Diabetes Versus Atrial Fibrillation

By MedXY 09/11/2026

This study analyzes global trends comparing ischemic stroke burdens linked to diabetes and atrial fibrillation, revealing a rising impact of diabetes-related stroke and highlighting the need for targeted interventions.

Clinical Updates Neurology news

Smoking, Exhaled Carbon Monoxide, and Parkinson’s Disease Risk: Epidemiological Insights and Mechanistic Perspectives

By MedXY 09/11/2026

This review explores evidence linking smoking and exhaled carbon monoxide levels to reduced Parkinson's disease risk, emphasizing a potential protective role of carbon monoxide, supported by recent large-scale cohort data and biological insights into PD pathophysiology.

Neurology news

Common MC1R Variants and Parkinson Disease Progression

By MedXY 09/11/2026

This study links MC1R loss-of-function variants to faster motor decline and phenoconversion in Parkinson's disease, suggesting their value for prognosis and clinical trial design in European descent patients.