Highlight
This 10-year prospective cohort study investigated surgical management of peri-implantitis combining deproteinised bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD), and doxycycline powder for implant surface decontamination and defect fill. Key findings demonstrate a high implant survival rate (96.6%) and significant improvements in probing depths and bone levels with stable clinical outcomes over a decade. Individualised supportive peri-implant therapy (SPIT) played a critical role in long-term maintenance and adjunctive antibiotic use.