Integrated Intraocular and Plasma Proteomics Identify Neurofilament Light Chain as a Conserved Biomarker for Diabetic Retinopathy Progression: A Multi-Fluid Biopsy Perspective
Posted inClinical Updates news

Integrated Intraocular and Plasma Proteomics Identify Neurofilament Light Chain as a Conserved Biomarker for Diabetic Retinopathy Progression: A Multi-Fluid Biopsy Perspective

This review synthesizes evidence on neurofilament light chain (NFL) as a minimally invasive plasma biomarker predictive of diabetic retinopathy progression and vascular complications, based on integrated intraocular-plasma proteomics and multi-cohort validations.
Decoding the Diabetic Heart: Five Unique Proteomic Markers Unveil Heart Failure Risk in Patients with Diabetes
Posted inCardiology Diabetes & Endocrinology news

Decoding the Diabetic Heart: Five Unique Proteomic Markers Unveil Heart Failure Risk in Patients with Diabetes

Researchers from the ARIC study have identified five specific proteomic markers that uniquely predict heart failure risk in individuals with diabetes. These findings, including four novel proteins, suggest distinct pathophysiological pathways for diabetic cardiomyopathy and offer new targets for precision screening and therapeutic intervention.
Proteomic Signatures in Atrial Fibrillation: Deciphering the Risk of Heart Failure Hospitalization and Ejection Fraction Phenotypes
Posted inCardiology news

Proteomic Signatures in Atrial Fibrillation: Deciphering the Risk of Heart Failure Hospitalization and Ejection Fraction Phenotypes

This study identifies key plasma biomarkers—including NT-proBNP, FGF-23, and GDF-15—that predict heart failure hospitalization in patients with atrial fibrillation. Findings also reveal distinct pathophysiological pathways for HFrEF and HFpEF, highlighting the roles of inflammation and adipose metabolism.