Large-scale proteomics identified 23 proteins associated with incident noncancer venous thromboembolism (VTE), with 15 being novel markers not previously linked to the disease.
Mendelian randomization (MR) provides evidence for a causal role of TIMD4, TIMP4, and Cystatin-C in the pathogenesis of VTE, highlighting non-clotting pathways.
Identified pathways include extracellular matrix (ECM) regulation, immunity, vascular endothelium interactions, and vascular senescence, suggesting a much broader etiology for VTE than Virchow’s Triad.
Clinical decision-making for intensive cardiovascular risk management in older adults is heavily influenced by frailty and age, though digital monitoring can mitigate clinical inertia.
