Proteomic profiling of maternal plasma revealed 87 proteins with differential abundance in fetal death cases versus controls.
New biomarkers including CGA, DNAJB9, and POLR3K significantly improved fetal death discrimination beyond placental growth factor and sFlt-1.
Shared but amplified proteomic changes were observed in fetal death with preeclampsia compared to live births, alongside distinct pathways exclusive to fetal death.
Random forest modeling incorporating novel proteins increased sensitivity for detecting fetal death from 53% to 74% at comparable false positives.
