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- Comprehensive proteomic and metabolomic profiling reveals 203 proteins and 16 metabolites significantly associated with cardiac structure and function in breast cancer patients undergoing anthracycline and/or trastuzumab therapy.
- Cathepsin C identified as a key protein linked to left ventricular ejection fraction (LVEF), longitudinal strain, left atrial volume index, and incident cardiac dysfunction.
- Enriched pathways include protein deubiquitination, protein modification, macromolecule catabolic processes, and global metabolic pathways, underscoring complex biological mechanisms underlying cardiotoxicity.
- Amino acid–related metabolites such as n-acetylglutamine and aspartic acid show strong associations with reductions in cardiac function metrics, pointing to metabolic alterations during cardiotoxic therapy.
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