Specialties – Page 23

Transcription Factor NFE2: A Crucial Regulator of Redox Balance and Chemotherapy Resistance in Acute Myeloid Leukemia

By MedXY 08/24/2026

NFE2 drives leukemic transformation through redox regulation, modulating glutathione homeostasis and detoxification pathways, and confers chemotherapy resistance in AML. Targeting NFE2 may enhance therapeutic efficacy and improve patient outcomes.

Hematology-Oncology news Oncology

Oncogenic DHX15 Mutation Drives Mitochondrial Metabolism to Sustain Leukemia Stemness in AML

By MedXY 08/24/2026

A hotspot DHX15R222G mutation collaborates with AML1-ETO fusion to enhance mitochondrial function and leukemia stem cell activity, leading to poorer prognosis and chemotherapy resistance in AML, unveiling OXPHOS inhibition as a promising targeted therapy.

Hematology-Oncology news

Sustained Genetic Silencing of BCL11A Using shmiR Vector in Sickle Cell Disease: Long-Term Safety and Efficacy

By MedXY 08/24/2026

This article reviews the first-in-human study demonstrating durable and safe posttranscriptional silencing of BCL11A in sickle cell disease patients using a shmiR vector, resulting in stable fetal hemoglobin induction and clinical benefit over 4+ years.

Cardiology news Respiratory

Linking Pulmonary and Cardiac Health: Centrilobular Emphysema as a Predictor of Coronary Artery Calcification Progression

By MedXY 08/24/2026

Long-term data from lung cancer screening reveal centrilobular emphysema progression strongly associates with coronary artery calcification worsening, highlighting systemic vascular implications of this emphysema subtype.

news Radiology Respiratory

Incidental Emphysema Detected on Routine Screening Chest CT and Its Association with Mortality in a Korean Population

By MedXY 08/24/2026

This study evaluates the independent association between incidental emphysema found on routine screening chest CT scans and all-cause mortality in a large Korean cohort, highlighting implications for risk stratification among ever-smokers.

news Ophthalmology Pediatrics

Long-Term Outcomes of Strabismus Surgery in Children with Perinatal Brain Injury: Insights and Clinical Implications

By MedXY 08/24/2026

Children with perinatal brain injury exhibit lower long-term success rates following strabismus surgery, mainly due to undercorrection despite comparable surgical dosing. Larger preoperative deviations predict poorer outcomes, underscoring the need for tailored counseling and treatment strategies.

news Ophthalmology

Novel Peripheral Retinal Vascular Biomarker on Ultra-Widefield OCTA Enables Severity Grading in Retinitis Pigmentosa

By MedXY 08/24/2026

Ultra-widefield OCT angiography identifies distinct peripheral retinal vascular phenotypes and a quantitative CNZ biomarker, facilitating an objective four-stage grading system for retinitis pigmentosa severity assessment and clinical trial stratification.

news Ophthalmology

Impact of Trabeculectomy versus Medical Therapy on Visual Field and Quality of Life in Advanced Glaucoma: Insights from the TAGS Study

By MedXY 08/24/2026

The TAGS Study shows trabeculectomy slows visual field loss more effectively than medical treatment in advanced glaucoma, yet this did not translate into significant quality-of-life improvements over five years, highlighting limitations in current patient-reported outcome measures.

news Oncology Otorhinolaryngology

Enhanced Pathologic Responses with Neoadjuvant Chemoimmunotherapy in Resectable Head and Neck Squamous Cell Carcinoma

By MedXY 08/24/2026

Neoadjuvant chemoimmunotherapy significantly improves pathologic complete and major responses compared to immunotherapy alone in resectable head and neck squamous cell carcinoma, suggesting a promising avenue to improve treatment outcomes.

General Surgery news Otorhinolaryngology

Post-Bariatric Surgery Patulous Eustachian Tube: Weight Loss Velocity as a Predictor of Chronicity

By MedXY 08/24/2026

Weight loss velocity, rather than absolute weight loss, predicts the onset and persistence of Patulous Eustachian Tube symptoms after bariatric surgery, highlighting the need for close monitoring during rapid BMI decline phases.

Clinical Updates news Oncology Otorhinolaryngology

Impact of Neighborhood Socioeconomic Deprivation on Breslow Thickness and Clinical Outcomes in Head and Neck Cutaneous Melanoma: A Comprehensive Review

By MedXY 08/24/2026

This review synthesizes evidence linking neighborhood socioeconomic deprivation with increased Breslow thickness and delayed surgical management in head and neck cutaneous melanoma, highlighting potential mechanisms and clinical implications.

Diabetes & Endocrinology General Surgery news

Risk Factors and Management of Iatrogenic Hypercalcemia during Active Vitamin D Supplementation for Hypoparathyroidism Post-Total Thyroidectomy

By MedXY 08/24/2026

Iatrogenic hypercalcemia complicates 14% of hypoparathyroidism cases post-total thyroidectomy, linked to low early postoperative parathyroid hormone and early vitamin D initiation. Careful supplementation and monitoring are vital in preventing severe outcomes.

General Surgery news Psychiatry

Spiritual Distress Before Elective Surgery: Understanding Its Impact on Patient Experience and Outcomes

By MedXY 08/24/2026

This qualitative study reveals how spiritual distress shapes patients' fears and hopes before elective surgery, emphasizing the need for routine spiritual well-being assessment to support resilience and improve perioperative care.

Cardiology Diabetes & Endocrinology news

Parathyroidectomy Significantly Lowers Cardiovascular Risk in Primary Hyperparathyroidism: Insights from a Population-Wide Target Trial Emulation

By MedXY 08/24/2026

This population-wide study demonstrates that parathyroidectomy in primary hyperparathyroidism reduces major adverse cardiovascular events risk, particularly in patients with higher serum calcium levels.

Clinical Updates Neurology news OB/GYN & Women's Health

Feasibility and Patient-Centered Insights from a Pilot Trial of Home-Based Cognitive Training for Cognitive Impairment in Gynecologic Cancer Survivors

By MedXY 08/24/2026

This review synthesizes evidence on home-based cognitive training feasibility, adherence, and patient experiences in gynecologic cancer survivors with CRCI, highlighting clinical implications and directions for optimized intervention design.

news OB/GYN & Women’s Health Psychiatry

Mood Symptoms and Early Discontinuation of Contraceptive Methods: Insights from the HER Salt Lake Study

By MedXY 08/24/2026

This study explores how self-reported mood-related symptoms influence early discontinuation of hormonal and nonhormonal contraceptives, revealing complex interactions between baseline mood, contraceptive type, and discontinuation behavior.

Clinical Updates news OB/GYN & Women's Health

Deep Learning Applications in Evaluating and Predicting Technical Surgical Skills in Robotic-Assisted Vaginal Cuff Closure: A Multicenter Prospective Study

By MedXY 08/24/2026

This review synthesizes evidence on deep learning models for assessing technical skills and error detection in robotic-assisted vaginal cuff closure, emphasizing objective surgical skill evaluation, model accuracy, and implications for surgical education and credentialing.

Gastroenterology news

Gut: Targeting Kupffer Cell Autophagy May Be A Novel Approach to Modulate CD8+ T Cell Activation in Primary Biliary Cholangitis

By MedXY 08/24/2026

This article explores how autophagy in Kupffer cells influences CD8+ T cell activation and contributes to primary biliary cholangitis, highlighting potential therapeutic interventions targeting macrophage autophagy to alleviate liver inflammation and bile duct damage.

Gastroenterology General Surgery news

Gut: Unraveling the Role of CD177+ Neutrophils in Driving Liver Regeneration After ALPPS Surgery

By MedXY 08/24/2026

CD177+ neutrophils facilitate rapid liver regeneration post-ALPPS by promoting extracellular matrix remodeling and hepatocyte growth factor release, revealing new immunological insights and potential therapeutic avenues for liver failure.