Internal Medicine – Page 3

SRPK3-Driven TPM1 Splicing Emerges as a Myofilament Mechanism of Diastolic Dysfunction in HFpEF

By MedXY 06/09/2026

A Circulation study identifies SRPK3-mediated alternative splicing of TPM1 exon 9a as a driver of myofibrillar disarray, reduced myocardial compliance, and diastolic dysfunction in HFpEF, highlighting a potential disease-modifying therapeutic target.

Clinical Updates Gastroenterology Internal Medicine news

Primary vs Specialist Palliative Care in End-Stage Liver Disease: Interpreting the 2026 Cluster Randomized Trial in the Broader Evidence Base

By MedXY 06/09/2026

A major 2026 cluster randomized trial shows that palliative care delivered by trained hepatologists is noninferior to specialist palliative care for improving quality of life in end-stage liver disease, supporting scalable integrated models for cirrhosis and hepatocellular carcinoma.

Emergency Medicine Internal Medicine news

Point-of-Care Ultrasound in Acute Care Did More Than Diagnose: It Reassured Patients, Reduced Burden, and Deepened Trust

By MedXY 06/06/2026

A qualitative study found that patients experienced point-of-care ultrasound as emotionally reassuring, physically convenient, and closely tied to physician communication and trust during acute care.

Internal Medicine news Otorhinolaryngology

Higher Oral Corticosteroid Exposure in Chronic Rhinosinusitis With Nasal Polyps Is Linked to More Systemic Harm

By MedXY 06/06/2026

A nationwide Korean nested case-control study found that longer annual duration and higher cumulative oral corticosteroid dose in chronic rhinosinusitis with nasal polyps were associated with increased systemic adverse events, supporting steroid-sparing management.

Internal Medicine news Otorhinolaryngology

Routine Hospitalist Co-Management After Head and Neck Free Flap Surgery Was Linked to Fewer Escalations of Care, but Not Shorter Stay or Lower Mortality

By MedXY 06/06/2026

In a retrospective cohort of 362 head and neck free tissue transfer patients, routine hospitalist involvement was associated with fewer transfers to a higher level of care, without significant effects on length of stay, readmission, or 90-day mortality.

Internal Medicine Neurology news

Acetazolamide Fails to Improve Gait in Idiopathic Normal Pressure Hydrocephalus: Swedish DRAIN Trial

By MedXY 06/05/2026

In a Swedish randomized trial, low-dose acetazolamide did not improve gait in patients with idiopathic normal pressure hydrocephalus and caused more side effects than placebo, arguing against routine use as medical therapy.

Critical Care Internal Medicine news

Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial

By MedXY 06/05/2026

A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.

Emergency Medicine Internal Medicine news

One in Six Older Emergency Department Patients Has Delirium: New Multisite Data Highlight Missed Risk, Mixed Management, and Higher Hospital Use

By MedXY 06/04/2026

A large multisite cohort found delirium in 16% of older adults in the emergency department, including nearly 8% of those discharged, with strong links to dementia, acuity, hospitalization, and 30-day readmission.

Emergency Medicine Internal Medicine news

One in Six Older Adults Presenting to the Emergency Department Had Delirium, With Higher Admission and 30-Day Readmission Risk

By MedXY 06/04/2026

A large multi-site cohort found delirium in 16% of older ED patients, including many discharged home, and linked it to higher admission and 30-day readmission, underscoring the need for standardized screening and supportive care.

Cardiology Internal Medicine news

Bempedoic Acid Was Linked to Fewer Venous Thromboembolic Events in Statin-Intolerant Patients in CLEAR Outcomes

By MedXY 06/03/2026

In a post hoc analysis of CLEAR Outcomes, bempedoic acid was associated with a significantly lower risk of venous thromboembolism, including deep vein thrombosis and pulmonary embolism, among statin-intolerant patients at high cardiovascular risk.

Cardiology Internal Medicine news

Arrhythmia Burden and Clinical Responses Under Continuous Monitoring in Heart Failure: Observations From the ALLEVIATE-HF Trial

By MedXY 06/03/2026

Continuous ICM monitoring in heart failure found a high burden of atrial fibrillation, bradyarrhythmia, and VT/VF. Arrhythmias were linked to more interventions and higher hospitalization risk, but the congestion-management strategy did not change arrhythmia occurrence.

Cardiology Internal Medicine news

Higher Interleukin-6 Levels Predict Broad Cardiovascular Risk and Mortality Across Diverse Cohorts

By MedXY 05/31/2026

A pooled analysis of 59,396 participants found that higher serum IL-6 concentrations independently predicted nine cardiovascular and mortality outcomes, with consistent associations across key clinical subgroups.

Internal Medicine news Public Health

VA Health Professions Trainees Were Disrupted by COVID-19 but Became Meaningful Contributors to Clinical Care, Telehealth, and System Response

By MedXY 05/30/2026

A qualitative VA study found that COVID-19 reduced trainee learning opportunities and heightened safety concerns, yet trainees contributed substantially to care delivery, telehealth expansion, patient support, and local pandemic planning.

Internal Medicine news Public Health

Medicare Advantage Enforcement Has Been Inconsistent and Financially Modest Despite Expanding Federal Exposure

By MedXY 05/30/2026

A 2010-2023 analysis found that CMS enforcement against Medicare Advantage plans was highly variable, usually limited to modest monetary penalties, and more common among lower-rated contracts serving more socially vulnerable beneficiaries.

Diabetes & Endocrinology Internal Medicine news

Two-Year SURPASS-EARLY Findings Show Tirzepatide Outperforms Intensified Conventional Care in Early Type 2 Diabetes

By MedXY 05/30/2026

In adults with early type 2 diabetes inadequately controlled on metformin, tirzepatide produced greater 2-year reductions in HbA1c, body weight, and waist circumference than intensified conventional care, with substantially higher rates of normoglycemia.

Critical Care Internal Medicine news

Frequent Pre-Admission Ambulatory Visits May Flag Harmful Diagnostic Error Risk in High-Risk General Medicine Inpatients

By MedXY 05/27/2026

In a retrospective cohort of high-risk medical inpatients, frequent ambulatory care use before admission emerged as a predictor of harmful diagnostic error, highlighting a potentially actionable EHR-based signal for hospital diagnostic safety programs.

Gastroenterology Internal Medicine news

Metabolic Dysfunction Did Not Worsen Short-Term Survival in Severe Alcohol-Associated Hepatitis in a Global Prospective Cohort

By MedXY 05/26/2026

In a 32-center international cohort, cardiometabolic risk factors were common in alcohol-associated hepatitis but did not independently increase 180-day mortality after adjustment for liver disease severity and competing transplant risk.

Cardiology Internal Medicine news

Higher Lipoprotein(a) Marks Greater Coronary Risk Without Prior MI or Stroke, While Evolocumab Delivers Similar Relative Benefit and Larger Absolute Gains

By MedXY 05/25/2026

In VESALIUS-CV, elevated baseline Lp(a) independently predicted major coronary events, especially MI, in patients without prior MI or stroke. Evolocumab reduced relative risk similarly across Lp(a) levels, with numerically greater absolute benefit in those with higher Lp(a).

Critical Care Internal Medicine news

ICU Readmission Raises 60-Day Mortality Substantially Regardless of Frailty, but Frail Patients Carry the Highest Absolute Risk

By MedXY 05/22/2026

In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.

Internal Medicine news Public Health

ACP Calls for Stronger Oversight of Medicare Advantage to Protect Patients, Payment Accuracy, and Quality

By MedXY 05/22/2026

The American College of Physicians urges major reforms to Medicare Advantage, including more accurate payment, simpler quality measures, tighter oversight of marketing and prior authorization, and stronger transparency to better protect beneficiaries.