Critical Care – Page 2

ICU Readmission Raises 60-Day Mortality Substantially Regardless of Frailty, but Frail Patients Carry the Highest Absolute Risk

By MedXY 05/22/2026

In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.

Critical Care General Surgery news

ABRUPT2 Trial: 5% Albumin Reduced Fluid Requirements in Major Burn Resuscitation

By MedXY 05/20/2026

ABRUPT2 found that adding 5% albumin to lactated Ringer’s significantly reduced fluid needs in the first 48 hours after major burns, without clear differences in mortality, kidney injury, or healing time.

Cardiology Critical Care news

Cardiogenic Shock Care Still Varies Widely Across CICUs, Especially in the Choice of Inodilators

By MedXY 05/19/2026

A large CCCTN analysis found major institutional and patient-level variation in vasoactive drug selection for cardiogenic shock, highlighting persistent evidence gaps in choosing dobutamine, milrinone, and other vasoactive therapies.

Critical Care news Nursing & care

Difficulty Paying for Medical Care: Links to Psychological Distress and Healthcare Perceptions Among ICU Caregivers

By MedXY 05/18/2026

More than half of ICU caregivers in a multicenter U.S. study reported difficulty paying for patient care, and financial strain was linked to higher posttraumatic stress, anxiety, depression, decisional regret, and medical mistrust.

$New SCCM–ESICM Consensus Defines Refractory Septic Shock$

Critical Care Infectious Diseases news

New SCCM–ESICM Consensus Defines Refractory Septic Shock

By MedXY 05/15/2026

A new SCCM–ESICM Delphi consensus standardizes clinical criteria for refractory septic shock, focusing on persistent hypoperfusion, fluid unresponsiveness, high vasopressor needs, and bedside ultrasound when mixed shock is suspected.

Critical Care news Respiratory

More Enteral Protein Did Not Overcome Anabolic Resistance in Mechanically Ventilated Critical Illness

By MedXY 05/13/2026

In a randomized trial, a 40 g intraduodenal whey bolus increased amino acid availability but did not significantly raise postprandial muscle protein synthesis versus 20 g in critically ill ventilated adults.

Critical Care news Respiratory

Predicted Body Weight May Be Too High for Many Critically Ill Women: New Evidence Challenges a Core Assumption in Lung-Protective Ventilation

By MedXY 05/12/2026

A large analysis suggests the predicted body weight equation overestimates lung size in critically ill women, increasing the risk of higher driving pressures and contributing to excess mortality under standard tidal-volume targeting.

Critical Care Hematology-Oncology news

急性白血病危重成人患者的時間趨勢和預後因素：個體參與者數據薈萃分析

By MedXY 05/09/2026

這項涵蓋19國55個ICU的2003名患者研究發現，急性白血病危重患者總體ICU死亡率為45%，需機械通氣者達66%。年齡>65歲、AML診斷、化療期間入院等因素顯著增加死亡風險，但隨時間推移生存率有所改善。

Critical Care news Public Health

Household Income Decline and Job Loss Among Survivors of Critical Illness: A Nationwide Cohort Study

By MedXY 05/09/2026

A large South Korean study reveals critical illness survivors face severe socioeconomic consequences, with 27.6% experiencing income decline and 12.3% job loss within a year, disproportionately affecting high-income households despite universal health coverage.

Critical Care Emergency Medicine news

TEE-Guided Chest Compression Targeting During ED Resuscitation Did Not Improve Clinical Outcomes in Out-of-Hospital Cardiac Arrest

By MedXY 05/09/2026

In EXECT-CPR, transesophageal echocardiography-guided adjustment of compression site during emergency department CPR did not significantly improve ROSC or survival, despite signals of improved hemodynamics and no excess safety concerns.

Critical Care news Respiratory

In-hospital influenza vaccination is associated with reduced 1-year mortality in critical patients with chronic pulmonary disease: a real world target trial emulation

By MedXY 05/09/2026

In critically ill chronic pulmonary disease patients, receiving influenza vaccination during hospitalization reduces 1-year mortality by 12%, lowers 90-day mortality by 12%, decreases readmission risk by 13%, and reduces emergency visits by 23%, with safety non-inferior to non-vaccinated patients.

Critical Care news Respiratory

Continuous Subphenotype Probabilities Expose High-Risk Patients Hidden Within “Hypoinflammatory” Acute Respiratory Failure

By MedXY 05/05/2026

AHRF patients classified as hypoinflammatory are not prognostically uniform. Continuous biomarker-based probabilities reveal substantial mortality heterogeneity, especially below the binary 0.5 threshold, with implications for enrichment strategies in phenotype-guided critical care trials.

Cardiology Critical Care news

Earlier Mechanical Thrombectomy for Intermediate-Risk Pulmonary Embolism Improves Hemodynamics but Not In-Hospital Mortality

By MedXY 05/05/2026

In a multicenter retrospective study, early mechanical thrombectomy within 12 hours of pulmonary embolism diagnosis improved pulmonary artery pressure reduction and reduced intubation, but did not significantly lower in-hospital mortality.

$Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus$

Critical Care Neurology news

Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus

By MedXY 04/30/2026

In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting urgent neuroprotective treatment.

Cardiology Critical Care news

Circulatory Support Escalation in Cardiogenic Shock: Outcomes and Predictors of Success

By MedXY 04/28/2026

A multi-center study reveals that circulatory support escalation in cardiogenic shock is associated with higher mortality and complications, but certain patient factors can predict successful outcomes.

Critical Care Infectious Diseases news

Biomarker Signatures in Sepsis: Linking Host Response to Clinical Outcomes

By MedXY 04/28/2026

A prospective cohort study identifies biomarker signatures for host resistance, disease tolerance, and damage in sepsis, revealing associations with mortality and sepsis subtypes.

Cardiology Critical Care news

Early Resistance Training and Verticalization During ECMO: A Safe Path to Improved Functional Outcomes

By MedXY 04/28/2026

A structured exercise program combining mobility therapy and resistance training in ECMO patients proved feasible and safe, with longer session times correlating with better functional performance.

Critical Care Infectious Diseases news

Cultural Diversity in ICU: A Protective Factor Against Sepsis Mortality

By MedXY 04/24/2026

A multicenter study reveals that culturally and linguistically diverse patients with sepsis had lower in-hospital mortality and shorter ICU stays compared to non-CaLD patients, challenging prior assumptions about healthcare disparities.

Critical Care Infectious Diseases news

Antifungal Therapy Slashes Mortality in COVID-19-Associated Pulmonary Aspergillosis: European Data Confirms

By MedXY 04/23/2026

A multicenter European cohort study demonstrates that antifungal treatment significantly reduces 60-day mortality in COVID-19-associated pulmonary aspergillosis (CAPA), particularly in immunocompromised patients. Key findings underscore the urgency of CAPA screening and targeted therapy in critical care settings.

Critical Care Emergency Medicine news

Higher EMS Clinician Trauma Volume Linked to Lower Early Mortality in Trauma Patients

By MedXY 04/23/2026

A study finds that increased annual trauma patient volume per EMS clinician is associated with significantly reduced 6-hour and in-hospital mortality rates, highlighting the importance of experience in prehospital trauma care.