Critical Care – Page 3

Impact of Appropriate Antimicrobial Therapy on ICU Patient Outcomes: Subanalysis of the DIANA Study Dataset

By MedXY 06/05/2026

In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.

Critical Care Internal Medicine news

Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial

By MedXY 06/05/2026

A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.

Cardiology Critical Care Emergency Medicine news Pediatrics

Extracorporeal Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest

By MedXY 06/02/2026

In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were imprecise.

Critical Care Neurology news

Avoiding Intensive Systolic Blood Pressure Lowering After Successful Thrombectomy May Improve 1-Year Stroke Recovery: The OPTIMAL-BP Extension

By MedXY 05/31/2026

In OPTIMAL-BP 1-year follow-up, targeting systolic BP <140 mm Hg after successful thrombectomy was associated with worse long-term functional recovery than conventional BP management.

Critical Care news Respiratory

Four Oxygenation Trajectories Define Reproducible Clinical Archetypes in Persistent Acute Respiratory Failure

By MedXY 05/31/2026

A multi-cohort study identified four reproducible 14-day oxygenation trajectory classes in persistent acute hypoxemic respiratory failure, with distinct mortality, biomarker patterns, and links to ARDS and hyperinflammatory subphenotypes.

Cardiology Critical Care news

Liberal Transfusion Still Appears Favored in Myocardial Infarction With Anemia, Regardless of Critical Illness Status

By MedXY 05/30/2026

A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.

Critical Care news Respiratory

Prone Positioning for Severe Hypoxemia Rose Sharply During COVID-19 but Was Not Sustained Across North American ICUs

By MedXY 05/27/2026

In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.

Critical Care Dermatology news

Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort

By MedXY 05/27/2026

In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.

Critical Care Internal Medicine news

Frequent Pre-Admission Ambulatory Visits May Flag Harmful Diagnostic Error Risk in High-Risk General Medicine Inpatients

By MedXY 05/27/2026

In a retrospective cohort of high-risk medical inpatients, frequent ambulatory care use before admission emerged as a predictor of harmful diagnostic error, highlighting a potentially actionable EHR-based signal for hospital diagnostic safety programs.

Critical Care news Respiratory

Out-of-Bed Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients

By MedXY 05/23/2026

A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.

Critical Care Internal Medicine news

ICU Readmission Raises 60-Day Mortality Substantially Regardless of Frailty, but Frail Patients Carry the Highest Absolute Risk

By MedXY 05/22/2026

In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.

Critical Care General Surgery news

ABRUPT2 Trial: 5% Albumin Reduced Fluid Requirements in Major Burn Resuscitation

By MedXY 05/20/2026

ABRUPT2 found that adding 5% albumin to lactated Ringer’s significantly reduced fluid needs in the first 48 hours after major burns, without clear differences in mortality, kidney injury, or healing time.

Cardiology Critical Care news

Cardiogenic Shock Care Still Varies Widely Across CICUs, Especially in the Choice of Inodilators

By MedXY 05/19/2026

A large CCCTN analysis found major institutional and patient-level variation in vasoactive drug selection for cardiogenic shock, highlighting persistent evidence gaps in choosing dobutamine, milrinone, and other vasoactive therapies.

Critical Care news Nursing & care

Difficulty Paying for Medical Care: Links to Psychological Distress and Healthcare Perceptions Among ICU Caregivers

By MedXY 05/18/2026

More than half of ICU caregivers in a multicenter U.S. study reported difficulty paying for patient care, and financial strain was linked to higher posttraumatic stress, anxiety, depression, decisional regret, and medical mistrust.

$New SCCM–ESICM Consensus Defines Refractory Septic Shock$

Critical Care Infectious Diseases news

New SCCM–ESICM Consensus Defines Refractory Septic Shock

By MedXY 05/15/2026

A new SCCM–ESICM Delphi consensus standardizes clinical criteria for refractory septic shock, focusing on persistent hypoperfusion, fluid unresponsiveness, high vasopressor needs, and bedside ultrasound when mixed shock is suspected.

Critical Care news Respiratory

More Enteral Protein Did Not Overcome Anabolic Resistance in Mechanically Ventilated Critical Illness

By MedXY 05/13/2026

In a randomized trial, a 40 g intraduodenal whey bolus increased amino acid availability but did not significantly raise postprandial muscle protein synthesis versus 20 g in critically ill ventilated adults.

Critical Care news Respiratory

Predicted Body Weight May Be Too High for Many Critically Ill Women: New Evidence Challenges a Core Assumption in Lung-Protective Ventilation

By MedXY 05/12/2026

A large analysis suggests the predicted body weight equation overestimates lung size in critically ill women, increasing the risk of higher driving pressures and contributing to excess mortality under standard tidal-volume targeting.

Critical Care Hematology-Oncology news

急性白血病危重成人患者的時間趨勢和預後因素：個體參與者數據薈萃分析

By MedXY 05/09/2026

這項涵蓋19國55個ICU的2003名患者研究發現，急性白血病危重患者總體ICU死亡率為45%，需機械通氣者達66%。年齡>65歲、AML診斷、化療期間入院等因素顯著增加死亡風險，但隨時間推移生存率有所改善。

Critical Care news Public Health

Household Income Decline and Job Loss Among Survivors of Critical Illness: A Nationwide Cohort Study

By MedXY 05/09/2026

A large South Korean study reveals critical illness survivors face severe socioeconomic consequences, with 27.6% experiencing income decline and 12.3% job loss within a year, disproportionately affecting high-income households despite universal health coverage.

Critical Care Emergency Medicine news

TEE-Guided Chest Compression Targeting During ED Resuscitation Did Not Improve Clinical Outcomes in Out-of-Hospital Cardiac Arrest

By MedXY 05/09/2026

In EXECT-CPR, transesophageal echocardiography-guided adjustment of compression site during emergency department CPR did not significantly improve ROSC or survival, despite signals of improved hemodynamics and no excess safety concerns.