Critical Care – Page 3

Elevated Preoperative Serum Renin Predicts Vasopressor Need and Acute Kidney Injury in Liver Transplant Patients

By MedXY 08/17/2026

Pre-liver transplantation elevated serum renin levels correlate with increased intraoperative vasopressor use and postoperative acute kidney injury, suggesting its potential as a predictive biomarker for perioperative management and renal risk stratification.

Critical Care Diabetes & Endocrinology news

Timing Matters: Early Insulin Therapy Reduces Mortality in ICU Patients with Moderate Hyperglycemia

By MedXY 08/17/2026

Early initiation of insulin within two hours for moderate hyperglycemia in ICU patients significantly lowers 30-day mortality compared to delayed or no insulin therapy. This target trial emulation highlights the potential clinical benefit of prompt insulin treatment timing in critical care.

Critical Care Nephrology news

Net Ultrafiltration Rate and Mortality in Critically Ill CRRT Patients: The Crucial Role of Fluid Balance

By MedXY 08/16/2026

A multicenter cohort study shows that in critically ill patients undergoing continuous renal replacement therapy, mortality is more closely associated with fluid balance changes than net ultrafiltration rate, emphasizing patient-specific fluid balance targets in care.

AI Critical Care news

Revolutionizing Oxygen Therapy: Autonomous Titration Enhances Normoxemia in Acutely Ill Adults

By MedXY 08/16/2026

The SAVE-O2 AI trial demonstrates autonomous oxygen titration significantly improves normoxemia maintenance and reduces hypoxemia duration compared to manual methods in hospitalized acutely ill adults.

Critical Care news Psychiatry

Psychoactive Medication Prescribing After Critical Illness in American Adults Not Justified by a Documented Supporting Diagnosis

By MedXY 08/15/2026

Nearly half of psychoactive medications newly prescribed after ICU stays in American adults lack documented diagnostic justification, persisting for up to two years post-hospitalization.

Critical Care Emergency Medicine news

Evaluating a Simplified Binary Triage System for Military Trauma: Balancing Accuracy and Operational Feasibility

By MedXY 08/14/2026

A judgment-based binary triage system demonstrated high sensitivity and low undertriage rates in military trauma, supporting its use despite significant overtriage under combat conditions.

Critical Care Internal Medicine news

Ultra-Early Versus Early Vasopressin Initiation After Norepinephrine Escalation in Septic Shock: Insights from a Target Trial Emulation

By MedXY 08/12/2026

This study emulated a target trial to compare ultra-early (0-3h) versus early (>3-6h) vasopressin initiation after norepinephrine escalation in septic shock, revealing significant mortality and renal therapy benefits with ultra-early use.

Critical Care Nephrology news

Unraveling the Complex Benefits and Risks of Renal Replacement Therapy in ICU Patients: Insights from a Japanese Registry

By MedXY 08/12/2026

This study highlights varied outcomes of renal replacement therapy in critically ill patients, identifying subgroups who may benefit despite an overall increase in mortality risk.

Allergy & Immunology Critical Care Emergency Medicine news

Evaluating the Impact of a Prehospital 1-Hour Resuscitation Bundle on Septic Shock Mortality: Insights from the SAMU Save Sepsis Study

By MedXY 08/11/2026

A multicenter randomized trial found that initiating a 1-hour resuscitation bundle including early antibiotics, fluids, vasopressors, and hydrocortisone in the prehospital setting did not significantly reduce 28-day mortality in adults with septic shock.

Allergy & Immunology Critical Care news

Functional Impairment of Natural Killer Cells After Severe Trauma: Phenotypic Shifts and Loss of Activating Receptors

By MedXY 08/11/2026

Severe trauma induces maturation and cytotoxic phenotypes in NK cells but paradoxically decreases expression of activating receptors critical for immune defense, revealing a mechanism underlying posttrauma immune dysregulation and vulnerability to infection.

Critical Care Emergency Medicine news

Impact of Rocuronium Dose on First-Attempt Intubation Success in Critically Ill Patients: Insights from a Secondary Analysis of Multicenter Trials

By MedXY 08/11/2026

High-dose rocuronium (>1.2 mg/kg) is associated with improved first-attempt intubation success in ICU patients, though this benefit was not observed in the ED setting. Further randomized trials are needed to confirm these findings.

Critical Care Emergency Medicine news

Evaluating the Impact of a 1-Hour Prehospital Resuscitation Bundle on Septic Shock Outcomes

By MedXY 08/11/2026

A multicenter study investigated whether initiating a 1-hour resuscitation bundle—including antibiotics, fluids, vasopressors, and hydrocortisone—in the prehospital setting influences 28-day mortality in septic shock, finding no significant mortality benefit.

Critical Care Emergency Medicine news

High-Dose Rocuronium Enhances First-Attempt Intubation Success in Critically Ill ICU Patients: Insights from Secondary Analysis of Multicenter Trials

By MedXY 08/11/2026

Secondary analysis of two multicenter trials reveals that high-dose rocuronium (>1.2 mg/kg) improves first-attempt intubation success in ICU patients but not in the emergency department, highlighting a potential dose-dependent effect on airway management outcomes.

Allergy & Immunology Critical Care news

Dynamic Alterations in Natural Killer Cell Phenotype and Activating Receptor Expression Following Trauma: Insights into Immune Dysregulation

By MedXY 08/11/2026

Severe trauma induces phenotypic maturation of natural killer cells but leads to a loss of key activating receptors, potentially driving posttraumatic immune dysfunction and increased infection risk.

Critical Care news Pediatrics

Ultrasound-Guided Brachiocephalic Venipuncture for Neonatal Central Venous Access: A Multicenter Study Validating Safety and Feasibility

By MedXY 08/10/2026

This multicenter observational study demonstrates that ultrasound-guided supraclavicular brachiocephalic vein cannulation is a feasible, safe, and reproducible method for central venous catheter placement in critically ill neonates, with a high first-attempt success and low complication rates.

Critical Care news OB/GYN & Women’s Health

Impact of Texas Abortion Ban on Critical Illness in Hospitalized Pregnant Women: A Retrospective Cohort Analysis

By MedXY 08/10/2026

The Texas Senate Bill 8 abortion ban is linked to an increased rate of critical illness, sepsis, and infections among hospitalized pregnant women with high-risk features, highlighting significant implications for maternal healthcare in restrictive states.

Critical Care Nephrology news

H3.1 Nucleosomes as Predictive Biomarkers for Renal Replacement Therapy and Mortality in Sepsis: Insights from the SISPCT Trial

By MedXY 08/07/2026

Elevated plasma levels of H3.1 nucleosomes at ICU admission correlate with increased mortality and acute kidney injury requiring renal replacement therapy in sepsis, highlighting their potential as prognostic biomarkers.

Critical Care news Respiratory

Interleukin-6 as a Central Mediator of Therapeutic Success in Acute Lung Injury and COVID-19

By MedXY 08/06/2026

This article examines interleukin-6 (IL-6) as a key mediator of therapeutic efficacy in acute lung injury and COVID-19, highlighting its role in modulating inflammation and survival outcomes across multiple clinical interventions.

Critical Care Nephrology news

Evaluating Renal Resistive Index Responsiveness to MAP Targets in Early Septic Shock: Clinical Implications and Physiologic Insights

By MedXY 08/05/2026

This study explores whether renal resistive index (RRI) changes during a transient elevation of mean arterial pressure (MAP) can guide individualized MAP targets to optimize renal function in early septic shock, finding that RRI decrease does not predict improved outcomes with higher MAP, while lack of RRI decrease may identify patients benefiting from MAP elevation.

Critical Care news Public Health

Socioeconomic Status and Comorbidity Influence on ICU Mortality: Insights from a Dutch Nationwide Cohort

By MedXY 08/03/2026

This nationwide Dutch study reveals that lower socioeconomic status independently predicts increased ICU hospital mortality regardless of comorbidities, underscoring persistent health disparities in universal healthcare.