liver transplantation

Bridging the Gap: Global Disparities in Liver Transplantation and Disease Burden (2000-2023)

By MedXY 10/24/2026

This article analyzes global liver transplantation disparities relative to cirrhosis and chronic liver disease burden, revealing unequal access dominated by high-income countries and highlighting the role of health system development in transplantation capacity.

Clinical Updates news Transplantation

Impact of Poor Food Access on Metabolic Dysfunction-associated Liver Disease and Frailty Among Liver Transplant Candidates: A Geospatial Analysis

By MedXY 10/15/2026

Poor food access correlates with higher MASLD and frailty prevalence in liver transplant candidates, with geospatial clustering highlighting socioeconomic and environmental determinants impacting transplant candidacy and outcomes.

Gastroenterology Nephrology news

Assessing Survival Outcomes of Simultaneous Liver-Kidney Versus Liver Alone Transplantation in the Era of the 2017 OPTN Policy

By MedXY 10/13/2026

This analysis of over 63,000 US liver transplants reveals that simultaneous liver-kidney transplantation (SLKT) confers significant survival benefit only in patients with severe renal dysfunction (eGFR <30), with no advantage in those with better pretransplant kidney function. The 2017 OPTN policy reduced SLKT procedures without compromising survival, supporting stage-specific organ allocation and the 'Safety Net' approach.

Clinical Updates news Oncology Transplantation

Liver Transplantation for Hepatocellular Carcinoma: Prognostic Impact of Complete Pathologic Response and Influence of Treatment Modality—A US National Database Study

By MedXY 10/06/2026

Complete pathologic response (cPR) after locoregional therapies notably improves survival in hepatocellular carcinoma (HCC) patients undergoing liver transplantation. Yttrium-90 radioembolization shows superior cPR rates, particularly when administered early and in patients with higher tumor burden.

Clinical Updates news Oncology

Immune Checkpoint Inhibitor-Based Downstaging Therapy for Hepatocellular Carcinoma: Evidence, Outcomes, and Clinical Perspectives

By MedXY 10/05/2026

This review synthesizes recent evidence on immune checkpoint inhibitor (ICI)-based downstaging therapy for hepatocellular carcinoma (HCC) beyond Milan criteria prior to liver transplantation, highlighting improved oncologic outcomes alongside acute rejection risks.

Gastroenterology news

Mitigating Innate Immune Response in Liver Transplantation: Insights from HOPE and NMP Machine Perfusion

By MedXY 10/04/2026

This article reviews how hypothermic oxygenated and normothermic machine perfusion reduce hepatic and systemic inflammation after liver transplantation, improving immune regulation and clinical outcomes.

Gastroenterology news Public Health

Impact of Medicaid Expansion on Adult Liver Transplant Outcomes: A Decade-Long Analysis

By MedXY 10/02/2026

Medicaid expansion is associated with improved graft and patient survival following adult liver transplantation, highlighting the benefits of broader health insurance access on transplant outcomes.

Gastroenterology news Respiratory

Impaired Pulmonary Function and Dyspnea in Liver Transplant Recipients: Insights from a Nationwide Matched Cohort Study

By MedXY 10/02/2026

This study reveals that liver transplant recipients exhibit significantly reduced lung function and increased dyspnea compared to the general population, highlighting the need for heightened pulmonary surveillance in this vulnerable group.

Gastroenterology General Surgery news

Advancing Donation After Circulatory Death Liver Transplants: Comparing Normothermic Machine and Regional Perfusion Outcomes

By MedXY 10/02/2026

This study compares normothermic machine perfusion and normothermic regional perfusion in DCD liver transplants, demonstrating both advanced methods approach brain death graft survival and improve outcomes over static cold storage.

General Surgery news Transplantation

The Laennec Technique: Advancing Standardization in Right Robotic Donor Hepatectomies

By MedXY 09/21/2026

The Laennec technique offers a structured, anatomy-based robotic approach for right donor hepatectomies, demonstrating safety, feasibility, and zero biliary complications, potentially standardizing this complex procedure across centers.

Gastroenterology General Surgery news

Out-of-Hours Liver Transplantation: Identifying High-Risk Timeframes and Implications for Patient Outcomes

By MedXY 09/19/2026

A Swedish national retrospective study reveals that liver transplantations initiated between 17:00 and 05:59 are linked to significantly increased postoperative complications and healthcare costs, highlighting the need for optimized scheduling.

Gastroenterology General Surgery news

Integrative Muscle-Adipose Score (IMAS): Enhancing Sex-Sensitive Prognostication After Liver Transplantation

By MedXY 09/18/2026

The Integrative Muscle-Adipose Score (IMAS) combines muscle and fat measures into a sex-specific tool that accurately predicts long-term survival and postoperative complications in liver transplant recipients, outperforming existing models.

Gastroenterology General Surgery news

Comparative Real-World Outcomes of Hypothermic Oxygenated and Normothermic Machine Perfusion in Liver Transplantation

By MedXY 09/12/2026

This international cohort study evaluates hypothermic oxygenated perfusion (HOPE) versus normothermic machine perfusion (NMP) in liver transplantation, revealing comparable high graft survival despite differing donor risk profiles and highlighting the need for further research on NMP benefits in high-risk grafts.

Gastroenterology Neurology news Transplantation

Metabolite-Mediated Neurocognitive Revival Following Liver Transplantation: Insights into Cortical Network Reactivation

By MedXY 09/03/2026

Liver transplantation facilitates early neurocognitive recovery in end-stage liver disease patients by restoring cortical network activities, with S-methyl-5'-thioadenosine playing a pivotal neuroprotective role through modulating neuroinflammation.

Critical Care Nephrology news

Elevated Preoperative Serum Renin Predicts Vasopressor Need and Acute Kidney Injury in Liver Transplant Patients

By MedXY 08/17/2026

Pre-liver transplantation elevated serum renin levels correlate with increased intraoperative vasopressor use and postoperative acute kidney injury, suggesting its potential as a predictive biomarker for perioperative management and renal risk stratification.

General Surgery news Oncology

Long-Term Survival and Curative Potential of Liver Transplantation for Nonresectable Colorectal Liver Metastases: Insights from the SECA-II Study

By MedXY 08/14/2026

A decade-long follow-up of the SECA-II study demonstrates that liver transplantation in highly selected patients with nonresectable colorectal liver-only metastases yields substantial long-term survival and may offer curative potential even after relapse.

Gastroenterology General Surgery news

Outcomes of Colorectal Dysplasia and Cancer in Patients with PSC-IBD Undergoing Liver Transplantation and Colectomy: Insights from a Multicenter Study

By MedXY 07/15/2026

This multicenter retrospective study examines colorectal dysplasia and malignancy outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease undergoing liver transplantation and colectomy, revealing comparable 5-year survival despite advanced disease in those transplanted first.

Gastroenterology General Surgery news

Impact of Modified Frailty Index on Liver Transplant Outcomes: Insights from a Multicenter Cohort Study

By MedXY 07/08/2026

This study demonstrates that the 5-variable Modified Frailty Index effectively predicts short- and long-term morbidity and mortality after liver transplantation, supporting its use in pretransplant assessment and perioperative planning.

Gastroenterology news Oncology

RETREAT Score Stratifies Long-Term Hepatocellular Carcinoma Recurrence Risk After Liver Transplantation in Real-World Practice

By MedXY 06/07/2026

A single-center validation study shows the RETREAT score reliably predicts long-term HCC recurrence after liver transplantation and identifies patients with markedly different recurrence-free and overall survival trajectories.

Gastroenterology news Transplantation

Adult Liver Transplant Candidate Evaluation: What the New AASLD/AST Guideline Changes

By MedXY 06/05/2026

The updated AASLD/AST guideline clarifies how adults should be evaluated for liver transplantation, emphasizing equitable access, multidisciplinary assessment, psychosocial readiness, and structured risk–benefit decision-making.