gut microbiota – Medxy AI

Gut Microbiota and Metabolomic Signatures as Predictors of Immunotherapy Outcomes in MASLD and Viral HCC

By MedXY 08/22/2026

Distinct gut microbial profiles but shared metabolomic markers, especially fecal acetate, predict response and survival with combination immunotherapy in metabolic dysfunction-associated and viral hepatitis-related hepatocellular carcinoma.

Cardiology Clinical Updates Gastroenterology news

Gut Microbiota-Derived Imidazole Propionate as a Predictor of Cardiometabolic Risk in Coronary Artery Disease: Evidence and Clinical Implications

By MedXY 08/18/2026

Emerging evidence identifies circulating imidazole propionate, a gut microbiota-derived metabolite, as an independent predictor of major adverse cardiovascular events in patients with coronary artery disease, offering novel insights into personalized risk stratification and therapeutic targets.

Cardiology Gastroenterology news

Microplastic Exposure and Cardiomyopathy: Unveiling the Gut-Heart Axis Mechanism

By MedXY 07/14/2026

This study reveals that bisphenol F exposure aggravates cardiomyopathy under hemodynamic stress through gut microbiota metabolism, highlighting a novel gut-heart axis involving N-acetylputrescine and potential therapeutic targets.

Clinical Updates Internal Medicine news Rehabilitation Medicine

Gut-Muscle Axis: Roseburia inulinivorans as a Novel Mediator of Skeletal Muscle Strength and Fiber-Type Composition

By MedXY 03/11/2026

This clinical update synthesizes evidence on Roseburia inulinivorans, identifying it as a species-specific gut microbe that enhances muscle strength by modulating amino acid metabolism and skeletal muscle fiber types.

Gastroenterology news Oncology

Beyond Conventional Immunotherapy: Zhenqi Fuzheng Granule Synergizes with PD-1 Blockade by Remodeling Gut-Immune Metabolism in Colorectal Cancer

By MedXY 01/13/2026

Researchers have discovered that Zhenqi Fuzheng Granule enhances PD-1 antibody efficacy in colorectal cancer by modulating the gut microbiota-SCFA-GPR109A axis, effectively suppressing tumor glycolysis and reversing immune exhaustion within the tumor microenvironment.

Gastroenterology news Oncology

Microbial Metabolism Dysfunction and Its Impact on Liver Injury After TACE in Hepatocellular Carcinoma

By MedXY 10/27/2025

This review explores how gut microbiota disturbances, especially L. reuteri and its metabolite ILA, influence post-TACE liver injury and prognosis in HCC patients, highlighting potential microbiota-targeted therapies.

Gastroenterology Internal Medicine news

Gut Microbiota Dysbiosis in Cirrhotic Portal Hypertension: Unraveling Microbial Contributions to Disease Progression

By MedXY 10/09/2025

Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.

Gastroenterology news

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

By MedXY 10/09/2025

A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets beyond immunosuppression.

Clinical Updates Oncology Specialties

Deciphering the Role of Intratumoral Microbiota in Breast Cancer: Pathogenesis to Precision Therapeutics

By MedXY 09/30/2025

Intratumoral microbiota significantly influence breast cancer development, progression, and therapeutic response. Their diverse composition across subtypes presents diagnostic and prognostic opportunities. Emerging strategies target these microbes to improve treatment efficacy and overcome resistance.

Neurology Pediatrics Psychiatry Specialties

Unraveling ADHD: Gut Microbial Signatures and the Role of SCFA Deficiency in Symptom Pathogenesis

By MedXY 09/29/2025

Recent research reveals distinct gut microbial and metabolic profiles linked to ADHD symptoms, highlighting short-chain fatty acid deficiency as a key mechanism driving hyperactivity and inattention.

Clinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Enhancing Metformin Efficacy and Tolerability in Prediabetes Through a Fermentable Carbohydrate-Rich Diet

By MedXY 09/17/2025

A fermentable carbohydrate-enriched diet combined with metformin improves postprandial glycaemia, enhances GLP-1 secretion, and positively alters gut microbiota in prediabetic individuals, offering a personalized nutrition-pharmacology strategy for diabetes prevention.

Clinical Updates Family Medicine & Nutrition news Specialties

Early-Life Blueberry Consumption: Potential Benefits for Infant Allergy Resolution, Immune Modulation, and Gut Microbiome Development

By MedXY 09/16/2025

Daily blueberry intake during complementary feeding may enhance allergy symptom resolution, favorably influence immune biomarkers, and promote beneficial gut microbiota shifts in breastfed infants, suggesting new avenues for allergy prevention.

Family Medicine & Nutrition Gastroenterology news Specialties

Linarin as a Multifaceted Therapeutic Agent for NAFLD: Modulation of PI3K/Akt/mTOR, Autophagy, and Gut Microbiota

By MedXY 09/07/2025

Linarin shows promise in mitigating NAFLD by enhancing autophagy via PI3K/Akt/mTOR inhibition, reducing inflammation, and restoring gut microbiota balance, alongside activating the PDE4D/cAMP/PKA/CREB pathway to improve hepatic lipid metabolism and oxidative stress.

Gastroenterology news Specialties

Unraveling the Paradox: Why Smoking Benefits Ulcerative Colitis but Worsens Crohn’s Disease

By MedXY 09/04/2025

Recent research elucidates how smoking modulates gut microbiota and immune responses differently in ulcerative colitis and Crohn’s disease, explaining its protective effect in UC but detrimental role in CD.

Family Medicine & Nutrition news Specialties

Divergence of Gut Microbiota Mediated by Milk-Derived Small Extracellular Vesicles: Genomic Variation and Metabolic Modulation in Sugars, Amino Acids, and Purines

By MedXY 08/20/2025

Milk small extracellular vesicles select genomic variants in gut bacteria, altering sugar, amino acid, and purine metabolism, impacting microbiota differentiation and host neurodevelopmental outcomes.

Diabetes & Endocrinology Internal Medicine news Specialties

Microbiota-Mediated Weight Loss: Insights from the WLM3P Multicomponent Program in Obesity

By MedXY 08/18/2025

The WLM3P weight loss program significantly remodels gut microbiota, enriching beneficial bacteria such as Faecalibacterium, which associates with improved fat and visceral fat loss in adults with obesity compared to standard low-carb diets.

Family Medicine & Nutrition Neurology Specialties

Exploring the Gut Microbiota-Insomnia Connection: Evidence and Controversies

By MedXY 08/18/2025

A recent Mendelian randomization study suggests bidirectional causal links between specific gut bacteria and insomnia, highlighting potential microbiome-based interventions, though causality remains debated among experts.

Diabetes & Endocrinology news Specialties

Synergistic Effects of Metformin and Moderate FODMAP Diet in Improving Postprandial Glycemia and Gut Health in Prediabetes

By MedXY 08/17/2025

Combining metformin with a moderate FODMAP diet improves postprandial glucose control, enhances GLP-1 secretion, increases butyrate-producing gut bacteria, and reduces inflammation without worsening gastrointestinal side effects in prediabetic patients.

Cardiology Diabetes & Endocrinology Medical News news Specialties

Multifunctional Dietary Approach to Reduce Intestinal Inflammation in Cardiometabolic Risk Subjects: Insights from the SINFONI Project

By MedXY 08/11/2025

This article explores how a multifunctional dietary strategy can alleviate intestinal inflammation linked to cardiometabolic risk by modifying gut microbiota composition.

Clinical Updates Diabetes & Endocrinology news Respiratory Specialties

Clinical Advances in Akkermansia muciniphila-Based Interventions: Respiratory Symptom Relief, Muscle Strength Enhancement, and Obesity Management

By MedXY 08/08/2025

Recent clinical trials reveal the therapeutic potential of Akkermansia muciniphila strains in alleviating respiratory symptoms, improving muscle strength, and preventing diet-induced obesity in dogs.