Distinct gut microbial profiles correlate with specific ADHD core symptoms, with combined presentations showing greatest alterations.
Beneficial bacteria involved in short-chain fatty acid (SCFA) synthesis, especially Lactobacillus sanfranciscensis, are significantly reduced in ADHD patients.
Imidazoleacetic acid mediates the link between Lactobacillus sanfranciscensis abundance and inattention, suggesting a metabolic pathway connecting microbiota changes to ADHD symptoms.
Fecal microbiota transplantation in mice validates that restoring Lactobacillus sanfranciscensis ameliorates hyperactivity and inattention, while acetate supplementation specifically improves attention deficits.
