Highlight
- Hypertension is influenced not only by cardiac and renal factors but also by gut microbiota through intestinal serotonergic signaling.
- Hypertensive rats and humans exhibit decreased intestinal serotonin (5-HT) levels and vagal 5HT3a receptor signaling activity.
- Fecal microbiota transplantation (FMT) from hypertensive rats decreases intestinal 5-HT and vagal signaling in normotensive rats, suggesting microbiota-driven modulation.
- Restoring 5HT3a receptor signaling in colonic vagal neurons alleviates hypertension, indicating a potential therapeutic target.
