Specialties – Page 14

Urgent versus early ERCP in mild-to-moderate acute cholangitis: what the trial found

By MedXY 05/28/2026

In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.

Gastroenterology news Oncology

Targeting Oncomucin-Driven Immunosuppression Improves KRAS G12D Inhibition in Pancreatic Cancer

By MedXY 05/28/2026

Oncomucins such as MUC4 and MUC16 help pancreatic cancer evade immunity through EGFR/UNC5B signaling. Targeting these mucins may enhance KRAS G12D inhibitor efficacy and reduce tumor burden.

Neurology news Public Health

Rural-Urban Disparity in Postacute Care and 1-Year Outcomes After Ischemic Stroke

By MedXY 05/28/2026

Older stroke patients treated in rural hospitals received less inpatient rehabilitation and more skilled nursing facility care than urban patients, with fewer days at home over 1 year but similar overall mortality.

Neurology news Pediatrics

A New Steroid Option for Duchenne Muscular Dystrophy? What the Latest Vamorolone Study Means for Families

By MedXY 05/28/2026

A new study suggests vamorolone may preserve motor benefits seen with standard steroids in Duchenne muscular dystrophy while better protecting growth, though weight gain remains a concern.

Neurology news

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

By MedXY 05/28/2026

A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.

Diabetes & Endocrinology General Surgery news

Marked Preoperative TSH Elevation Signals More Difficult Thyroidectomy in Graves’ Disease

By MedXY 05/28/2026

In a large single-center cohort, Graves’ disease patients with preoperative TSH ≥10.0 μIU/mL had greater blood loss, larger preoperative thyroid enlargement, and longer operations, suggesting that avoiding iatrogenic hypothyroidism during surgical preparation may improve operative conditions.

Cardiology Diabetes & Endocrinology news

Younger Adults With Type 2 Diabetes Show a More Adverse Cardiometabolic Profile Than Older Adults

By MedXY 05/28/2026

Across four national cohorts, younger adults with type 2 diabetes had higher adiposity and triglycerides, while glycemia peaked in midlife and blood pressure and albuminuria rose with age, suggesting age-specific pathways to diabetes complications.

Diabetes & Endocrinology Gastroenterology news

Adolescent MASLD Plus PCOS Signals a Higher-Risk Cardiometabolic Trajectory Into Adulthood

By MedXY 05/28/2026

In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Automated Insulin Delivery Improves Glycemia During Labor and Early Postpartum in Type 1 Diabetes: Clinical Insights From the CIRCUIT Trial

By MedXY 05/28/2026

A prespecified CIRCUIT analysis found that Control-IQ closed-loop insulin delivery improved intrapartum time in range and reduced early postpartum hypoglycemia versus standard care in women with type 1 diabetes, without new safety concerns.

Cardiology General Surgery news

Routine Surgical Left Atrial Appendage Occlusion Did Not Improve 1-Year Outcomes in Valvular Surgery Patients Without Atrial Fibrillation: Insights From the OPINION Trial

By MedXY 05/28/2026

In OPINION, prophylactic left atrial appendage occlusion during valve surgery did not significantly lower stroke, TIA, or cardiovascular death at 1 year in patients without pre-operative atrial fibrillation.

Cardiology news

Implantable Monitor–Guided, Nurse-Led Diuretic Escalation Was Safe but Did Not Improve Outcomes in ALLEVIATE-HF

By MedXY 05/28/2026

In ALLEVIATE-HF, ICM-based high-risk detection linked to centralized nurse-managed diuretic intervention was safe, but did not significantly improve the hierarchical composite outcome versus observation.

Critical Care news Respiratory

Prone Positioning for Severe Hypoxemia Rose Sharply During COVID-19 but Was Not Sustained Across North American ICUs

By MedXY 05/27/2026

In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.

Emergency Medicine news Public Health

An Emergency Department Nudge-Based Strategy to Screen and Treat Patients With Alcohol Misuse

By MedXY 05/27/2026

A multicomponent emergency department workflow using screening, electronic prompts, and discharge decision support significantly increased naltrexone prescribing for patients with alcohol-related diagnoses.

Dermatology Infectious Diseases news

Large-Scale Meta-Analysis Finds Higher Influenza and Shingles Risk with JAK-STAT Inhibitors

By MedXY 05/27/2026

A large meta-analysis found JAK-STAT inhibitors slightly increased influenza, bronchitis, and herpes zoster risk, especially in atopic dermatitis, while serious and opportunistic infections were not significantly increased.

Critical Care Dermatology news

Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort

By MedXY 05/27/2026

In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.

Critical Care Internal Medicine news

Frequent Pre-Admission Ambulatory Visits May Flag Harmful Diagnostic Error Risk in High-Risk General Medicine Inpatients

By MedXY 05/27/2026

In a retrospective cohort of high-risk medical inpatients, frequent ambulatory care use before admission emerged as a predictor of harmful diagnostic error, highlighting a potentially actionable EHR-based signal for hospital diagnostic safety programs.

news Public Health Respiratory

COPD Cuts Life Expectancy in a Severity-Dependent Manner, With Losses Comparable to or Greater Than Diabetes and Smoking

By MedXY 05/27/2026

A large pooled US cohort study found that COPD substantially reduces life expectancy, even among never-smokers, with years of life lost increasing progressively from GOLD stage 1 through stage 4.

Hematology-Oncology news Pathology & Lab Medicine/Bệnh học

Elevated Von Willebrand Factor and Factor VIII Show Promise as Biomarkers for Diagnosis and Monitoring of Chronic Graft-Versus-Host Disease

By MedXY 05/27/2026

In a prospective cohort, VWF and FVIII were significantly elevated in chronic graft-versus-host disease, tracked with disease activity, and showed moderate diagnostic performance for early cGvHD.

Hematology-Oncology news Oncology

Activity of PROTAC MDM2 Degrader in Primary Leukemia Cells and PDX Models

By MedXY 05/27/2026

MD-265, a PROTAC MDM2 degrader, showed strong anti-leukemia activity in primary AML cells and mouse PDX models, outperformed a conventional MDM2 inhibitor, and spared normal stem cells relatively well.

Hematology-Oncology news Pathology & Lab Medicine/Bệnh học

Self-Reinforcing IL-1β Signaling Accelerates TCF3::HLF-Positive B-ALL Development and Relapse

By MedXY 05/27/2026

Researchers found that IL-1β signaling drives growth, relapse, and bone damage in TCF3::HLF-positive B-ALL, suggesting IL-1β blockade may offer a new treatment strategy.