Medxy AI – Page 22

Cost-effectiveness of Pembrolizumab for FIGO 2014 Stage III-IVA Cervical Cancer in the United States

By MedXY 05/20/2026

Pembrolizumab plus chemoradiotherapy improved survival and quality-adjusted survival for FIGO 2014 stage III-IVA cervical cancer and was projected to be cost-effective in the U.S. at a $150,000/QALY threshold.

news OB/GYN & Women’s Health Pathology & Lab Medicine/Bệnh học

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

By MedXY 05/20/2026

This study links PCOS-related miscarriage risk to gut microbiome changes, especially reduced Parabacteroides merdae and higher isoleucine, which may promote endometrial senescence and impair pregnancy outcomes.

news OB/GYN & Women’s Health Public Health

Association Between Racial Segregation of Labor and Delivery Services and Use of Trial of Labor and Vaginal Birth After Cesarean

By MedXY 05/20/2026

Hospitals that serve more Black patients had higher rates of trial of labor after cesarean and VBAC success among low-risk patients, suggesting hospital practices may influence cesarean-related disparities.

Gastroenterology Infectious Diseases news

Diabetes, Male Sex, and Low HBsAg, HDV RNA, and ALT Predict Spontaneous HDV Suppression in Chronic Hepatitis D

By MedXY 05/20/2026

In 1,610 untreated chronic hepatitis D patients, spontaneous HDV suppression was uncommon but increased over time. Diabetes, male sex, and lower baseline HBsAg, HDV RNA, and ALT predicted suppression and fewer liver-related events.

Gastroenterology news Oncology

Targeting MLCK1 May Separate Immune Checkpoint Inhibitor Colitis From Antitumour Benefit

By MedXY 05/20/2026

A Gut study identifies MLCK1-driven epithelial barrier failure as a central mechanism in immune checkpoint inhibitor colitis and suggests epicatechin as a barrier-protective strategy that preserves antitumour efficacy in preclinical models.

Neurology news Public Health

Long-Term Cognitive Recovery After Stroke: What the Oxford Cognitive Screen Reveals

By MedXY 05/20/2026

A long-term stroke study found that cognition improves most within 6 months, with memory and language recovering better than executive function. Early cognitive impairment was the strongest predictor of outcomes years later.

Neurology news

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

By MedXY 05/20/2026

In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.

General Surgery Internal Medicine news Otorhinolaryngology

Fatigue After Thyroidectomy: What Patients Actually Experience

By MedXY 05/20/2026

A qualitative study found that fatigue after thyroidectomy is common, disruptive, and often unexpected. Patients described major impacts on work and daily life, and many wanted surgeons to warn them about it before surgery.

Clinical Updates Diabetes & Endocrinology news

Synergistic Protection of Pancreatic Beta Cells: GLP1-E2 and Low-Dose Anti-CD3 Combination Therapy in Autoimmune Diabetes

By MedXY 05/20/2026

Recent studies demonstrate that combining the beta-cell-targeted conjugate GLP1-E2 with low-dose anti-CD3 therapy significantly delays type 1 diabetes onset by simultaneously reducing immune infiltration and mitigating beta-cell cellular stress.

Diabetes & Endocrinology news Pediatrics

Children Born SGA Receiving Growth Hormone Have Similarly Impaired Glucose-Insulin Metabolism as Children With Obesity

By MedXY 05/19/2026

Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.

Diabetes & Endocrinology news Public Health

A U-Shaped Association Between Blood mtDNA Copy Number and Risk of Type 2 Diabetes

By MedXY 05/19/2026

Blood mtDNA copy number showed a U-shaped association with future type 2 diabetes risk in younger adults, suggesting that both low and high levels may signal higher risk.

Cardiology Critical Care news

Cardiogenic Shock Care Still Varies Widely Across CICUs, Especially in the Choice of Inodilators

By MedXY 05/19/2026

A large CCCTN analysis found major institutional and patient-level variation in vasoactive drug selection for cardiogenic shock, highlighting persistent evidence gaps in choosing dobutamine, milrinone, and other vasoactive therapies.

Cardiology news

Validated EMPEROR-Preserved Risk Models Stratify Prognosis in FINEARTS-HF, While Finerenone Benefits Remain Consistent Across Baseline Risk

By MedXY 05/19/2026

In FINEARTS-HF, EMPEROR-Preserved biomarker-based risk models showed good prognostic discrimination in HFmrEF/HFpEF, and finerenone’s relative treatment effect was consistent across the full baseline risk spectrum.

Cardiology news

Outcomes of Heart Failure With Reduced, Mildly Reduced, or Preserved Ejection Fraction: ESC HF III Registry

By MedXY 05/19/2026

The ESC HF III Registry found substantial mortality and rehospitalization across heart failure phenotypes. Risk was highest after acute hospitalization and generally worse with reduced ejection fraction, but HFmrEF and HFpEF also carried significant one-year event rates.

Cardiology news

Multiarterial Grafting and Survival After Coronary Artery Bypass Grafting: An Instrumental Variable Analysis

By MedXY 05/19/2026

In a large Medicare study, multiarterial grafting after CABG looked beneficial in standard analysis, but the advantage disappeared with instrumental variable adjustment, suggesting earlier observational studies may have overestimated survival benefit.

Cardiology news

Evolocumab in Patients With Prior Percutaneous Coronary Intervention and No Prior MI: Results From the VESALIUS-CV Trial

By MedXY 05/19/2026

In patients with prior PCI but no prior MI, evolocumab significantly lowered LDL-C and reduced major cardiovascular events, including myocardial infarction and urgent revascularization, supporting intensive lipid lowering after coronary intervention.

news Oncology Radiology

Reduced Preoperative Radiotherapy to 36 Gy Maintains Excellent Long-Term Local Control in Myxoid Liposarcoma

By MedXY 05/19/2026

Long-term phase 2 data suggest that 36 Gy preoperative radiotherapy for localized myxoid liposarcoma preserves excellent local control while limiting wound and late toxic effects.

news Psychiatry

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

By MedXY 05/19/2026

Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.

Critical Care news Nursing & care

Difficulty Paying for Medical Care: Links to Psychological Distress and Healthcare Perceptions Among ICU Caregivers

By MedXY 05/18/2026

More than half of ICU caregivers in a multicenter U.S. study reported difficulty paying for patient care, and financial strain was linked to higher posttraumatic stress, anxiety, depression, decisional regret, and medical mistrust.

Cardiology Emergency Medicine news

Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes

By MedXY 05/18/2026

A multicenter emergency department study found that CPES performed similarly to sPESI and ESC for short-term PE outcomes, but it better predicted the need for advanced intervention.

Cost-effectiveness of Pembrolizumab for FIGO 2014 Stage III-IVA Cervical Cancer in the United States

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

Association Between Racial Segregation of Labor and Delivery Services and Use of Trial of Labor and Vaginal Birth After Cesarean

Diabetes, Male Sex, and Low HBsAg, HDV RNA, and ALT Predict Spontaneous HDV Suppression in Chronic Hepatitis D

Targeting MLCK1 May Separate Immune Checkpoint Inhibitor Colitis From Antitumour Benefit

Long-Term Cognitive Recovery After Stroke: What the Oxford Cognitive Screen Reveals

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

Fatigue After Thyroidectomy: What Patients Actually Experience

Synergistic Protection of Pancreatic Beta Cells: GLP1-E2 and Low-Dose Anti-CD3 Combination Therapy in Autoimmune Diabetes

Children Born SGA Receiving Growth Hormone Have Similarly Impaired Glucose-Insulin Metabolism as Children With Obesity

A U-Shaped Association Between Blood mtDNA Copy Number and Risk of Type 2 Diabetes

Cardiogenic Shock Care Still Varies Widely Across CICUs, Especially in the Choice of Inodilators

Validated EMPEROR-Preserved Risk Models Stratify Prognosis in FINEARTS-HF, While Finerenone Benefits Remain Consistent Across Baseline Risk

Outcomes of Heart Failure With Reduced, Mildly Reduced, or Preserved Ejection Fraction: ESC HF III Registry

Multiarterial Grafting and Survival After Coronary Artery Bypass Grafting: An Instrumental Variable Analysis

Evolocumab in Patients With Prior Percutaneous Coronary Intervention and No Prior MI: Results From the VESALIUS-CV Trial

Reduced Preoperative Radiotherapy to 36 Gy Maintains Excellent Long-Term Local Control in Myxoid Liposarcoma

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

Difficulty Paying for Medical Care: Links to Psychological Distress and Healthcare Perceptions Among ICU Caregivers

Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes

Comparative 1-Year Outcomes of Semaglutide, Tirzepatide, and Sleeve Gastrectomy in Obese Adults with Type 2 Diabetes: Insights from Real-World Data

Unveiling the Phenotype of Unclassified Pulmonary Hypertension: A Hidden Spectrum of Early Heart Failure with Preserved Ejection Fraction

Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial

Decoding SLC4A3 Mutations in Short QT Syndrome: Insights from hiPSC-Derived Cardiomyocytes into Ventricular Arrhythmia and Sudden Cardiac Death