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The Multidose Ibuprofen Prior to Intrauterine device insertion (MIPI) trial provides high-level evidence supporting a preemptive, multidose regimen of ibuprofen to reduce pain during IUD insertion. The trial found significant and clinically meaningful reductions in pain intensity during the procedure compared to placebo. However, no significant differences were observed in pain 24 hours postinsertion or in additional analgesic usage.
