risk stratification – Page 4

Development and Validation of an Interpretable Hybrid Machine Learning Model for Predicting Long-term Lung Transplant Outcomes

By MedXY 12/13/2025

This review synthesizes evidence on a novel hybrid machine learning model leveraging US lung transplant registry data to predict mortality or retransplant risk at 1, 5, and 10 years, highlighting its clinical utility and balanced interpretability.

Cardiology news

Frailty after Acute Myocardial Infarction: A Stronger Predictor of 1‑Year Death in Younger Patients Than in the Elderly

By MedXY 12/02/2025

A large population study shows frailty is independently linked to worse 1‑year outcomes after AMI across ages, with the largest relative impact in patients under 55 — underscoring the need to assess frailty beyond geriatric populations.

news Oncology Respiratory

PLCOm2012 Risk-Based Selection Outperforms NELSON Criteria for Lung Cancer Detection in Germany: Findings from the HANSE Cohort

By MedXY 11/26/2025

In HANSE, PLCOm2012 (6‑year risk ≥1.58%) selected more lung cancers and yielded a lower number needed to screen than NELSON criteria, supporting risk-model selection for CT screening programs, with caveats on generalisability and mortality endpoints.

Neurology news Oncology

Validated IMPACT Tool Enables Risk‑Stratified Outpatient Management of Incidental Meningioma

By MedXY 11/23/2025

A large international cohort externally validated the IMPACT clinical tool, demonstrating accurate prediction of incidental meningioma progression and supporting triage to early intervention, serial monitoring, or safe discharge.

Critical Care news Radiology

Septal Curvature Ratio on CTPA Identifies Normotensive PE Patients at High Risk of Early Deterioration

By MedXY 11/06/2025

A multicentre prospective study shows the ventricular septum curvature ratio on CTPA strongly predicts 30‑day clinical deterioration in normotensive acute pulmonary embolism, outperforming conventional single metrics and offering potential for early risk stratification.

news Oncology Urology

Rethinking Gleason Grade Group 1 Prostate Cancer: Insights from a Large-Scale Cohort Study

By MedXY 10/27/2025

This study highlights the heterogeneity of GG1 prostate cancer and its implications for classification and management strategies.

Dermatology Hematology-Oncology news

T-Cell Receptor Clonotypes as Prognostic Markers in Cutaneous T-Cell Lymphoma: Insights from Next-Generation Sequencing

By MedXY 10/24/2025

This study identifies specific T-cell receptor clonotypes associated with aggressive subtypes and poorer survival in mycosis fungoides and Sézary syndrome, supporting TCR sequencing as a tool for refined risk stratification in cutaneous T-cell lymphoma.

Dermatology General Surgery Oncology

Refining Sentinel Lymph Node Biopsy Decisions in Melanoma: Insights from the MERLIN_001 Gene Expression Profiling Study

By MedXY 10/24/2025

The MERLIN_001 study validates a combined clinicopathological and gene expression profile test that accurately predicts sentinel lymph node metastasis risk in patients with cutaneous melanoma, potentially guiding safer, more personalized surgical decisions.

Cardiology Specialties

Enhanced GRACE 3.0 Score for Personalized Management of Non-ST-Elevation Acute Coronary Syndrome: Insights from a Multinational Validation Study

By MedXY 10/19/2025

The updated GRACE 3.0 scoring system improves mortality prediction and personalizes early invasive treatment decisions in non-ST-elevation acute coronary syndrome across ten countries, demonstrating excellent validation and clinical utility.

Cardiology Specialties Superintelligence

Harnessing Artificial Intelligence for Enhanced Prediction of Complete Heart Block Risk via Electrocardiography

By MedXY 09/27/2025

AIRE-CHB, a novel AI-enhanced ECG model, significantly improves prediction of incident complete heart block, outperforming traditional bifascicular block assessment and offering promising clinical utility in risk stratification and management.

Emergency Medicine Infectious Diseases news Pediatrics Public Health Specialties

Enhancing Early Risk Stratification of Severe Childhood Febrile Illness in Rural Asia Using sTREM1 Biomarker

By MedXY 08/30/2025

A multicountry study across Asia demonstrates soluble TREM1's superior accuracy over traditional clinical signs in predicting severe febrile illness in children, potentially transforming triage in resource-limited settings.

Cardiology Specialties Superintelligence

Advancing Acute Coronary Syndrome Care: ECG-Based Machine Learning Enhances Risk Stratification

By MedXY 08/16/2025

A prospective study shows that machine learning models trained on 12-lead ECG features outperform HEART score in predicting mortality among chest pain patients, improving risk-based care precision.

Clinical Updates news Oncology Specialties

Beyond Negative: Quantitative Fecal Hemoglobin Levels Refine Colorectal Cancer Risk Stratification in FIT-based Screening

By MedXY 08/06/2025

New meta-analysis reveals a strong dose-response relationship between fecal hemoglobin concentration and colorectal neoplasia risk, even among FIT-negative individuals, supporting personalized screening intervals.