Baseline Ischemic Burden Influences Tenecteplase Benefit Before Thrombectomy in Acute Stroke: Insights from the BRIDGE-TNK Trial
Posted inNeurology news

Baseline Ischemic Burden Influences Tenecteplase Benefit Before Thrombectomy in Acute Stroke: Insights from the BRIDGE-TNK Trial

A post hoc analysis of the BRIDGE-TNK trial reveals that intravenous tenecteplase before endovascular thrombectomy significantly improves functional independence in acute large-vessel occlusion stroke patients with extensive baseline ischemia (ASPECTS <8), while no benefit and potential risks occur in those with minor ischemia (ASPECTS 8-10).
The NIHSS Bias: Why Right-Sided Middle Cerebral Artery Strokes Carry Higher Mortality and Complication Risks
Posted inEmergency Medicine Neurology news

The NIHSS Bias: Why Right-Sided Middle Cerebral Artery Strokes Carry Higher Mortality and Complication Risks

A retrospective study of 489,360 patients reveals that right-sided middle cerebral artery strokes are associated with significantly higher inpatient mortality and complications compared to left-sided strokes, likely due to inherent scoring biases in the NIHSS that underestimate nondominant hemisphere deficits.
急性虚血性脳卒中における補助的静注アルガトロバンまたはエプチフィバチド投与：MOST無作為化臨床試験によるエビデンス
Posted inClinical Updates Neurology news

急性虚血性脳卒中における補助的静注アルガトロバンまたはエプチフィバチド投与：MOST無作為化臨床試験によるエビデンス

Recent multi-site randomized evidence demonstrates that adding intravenous argatroban or eptifibatide to standard thrombolysis within 3 hours of stroke onset does not improve functional recovery and is associated with increased mortality, including in patients undergoing mechanical thrombectomy.