Specialties – Page 3

Olfactory Receptor Signaling as a Novel Antiplatelet Strategy: OR2L13 Activation, HSP27 Phosphorylation, and Cytoskeletal Control of Arterial Thrombosis

By MedXY 06/10/2026

A 2026 Circulation study identifies OR2L13 agonism as a first-in-class platelet inhibitory strategy that suppresses aggregation and arterial thrombosis through HSP27-dependent actin remodeling without an apparent hemostatic penalty in preclinical models.

Cardiology news

WNT5a Signaling Disruption Drives Cardiac Pathogenesis in LMNA-Related Emery-Dreifuss Muscular Dystrophy

By MedXY 06/10/2026

Aberrant WNT5a-mediated actin filament dynamics underlie cardiac dysfunction and arrhythmias in LMNA-related Emery-Dreifuss Muscular Dystrophy, revealing novel therapeutic targets via RhoA activation and actin stabilization.

Neurology news Radiology

Wider Intracranial Arteries, Not Cranial Arterial Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease

By MedXY 06/10/2026

In a prospective mild stroke cohort, cranial arterial stenosis was not linked to cSVD, whereas basilar dolichoectasia and wider intracranial arteries were strongly associated with lacunar stroke, higher cSVD burden, incident infarcts, and white matter lesion progression.

Cardiology news

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

By MedXY 06/10/2026

ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.

General Surgery news

Role of Relaxing Lateral Incisions as an Add-On to Difficult Hiatal Repair in Redo and Giant Hernia Cases

By MedXY 06/10/2026

Lateral diaphragmatic relaxing incisions may help reduce tension during difficult hiatal hernia repair. In this retrospective series, most patients had improved reflux symptoms, but long-term recurrence data are still needed.

Gastroenterology General Surgery news

Role of Relaxing Lateral Incisions as an Add-On to Difficult Hiatal Repair in Redo and Giant Hernia Cases

By MedXY 06/10/2026

Lateral relaxing diaphragmatic incisions may help reduce tension during difficult hiatal hernia repairs, improving symptom control in redo and giant hernia cases, though long-term recurrence data are still needed.

Allergy & Immunology Cardiology news

Cardiac Sarcoidosis May Be Driven by a Heart-Resident Autoimmune B-Cell Axis Linked to Periplakin

By MedXY 06/10/2026

Single-cell and spatial transcriptomics suggest that cardiac sarcoidosis evolves through region-specific inflammatory programs and intracardiac B-cell autoimmunity, with periplakin emerging as a candidate autoantigen.

news Oncology Psychiatry

Longitudinal Risk for Suicidal Self-Directed Violence Among Veterans With Cancer

By MedXY 06/10/2026

A large study of veterans with cancer found persistent risk of suicidal self-directed violence, especially in younger, unmarried, frail, or mentally ill patients and those with central nervous system, head and neck, or thyroid cancers.

Cardiology news Public Health

Cold Weather Triggers Acute Heart Failure Decompensation, but Hemodynamic Phenotypes Show Opposite Temperature Risks

By MedXY 06/10/2026

A large Tokyo case-crossover study found that short-term exposure to low ambient temperature increases acute heart failure admissions, especially in older adults, while patients with hypotensive presentations may be more vulnerable to heat.

Gastroenterology news Oncology

Intraperitoneal and Intravenous Paclitaxel Plus S-1 for Gastric Cancer With Peritoneal Metastasis: Phase 3 Trial

By MedXY 06/10/2026

A phase 3 trial found that adding intraperitoneal paclitaxel to intravenous paclitaxel plus S-1 improved survival in gastric cancer with peritoneal metastasis without increasing severe toxicity.

Cardiology Diabetes & Endocrinology news

Precision Prescribing of SGLT2 Inhibitors in Type 2 Diabetes for Primary Prevention of Heart Failure

By MedXY 06/10/2026

A validation study developed SABRE, a model that estimates how much SGLT2 inhibitors can reduce heart failure risk in people with type 2 diabetes, helping clinicians target preventive treatment more precisely.

Cardiology Diabetes & Endocrinology news

Precision Prescribing of SGLT2 Inhibitors in People With Type 2 Diabetes for Primary Prevention of Heart Failure: Model Development and Validation Study

By MedXY 06/10/2026

The SABRE model estimates which people with type 2 diabetes may benefit most from SGLT2 inhibitors to prevent heart failure before it develops.

news Oncology Radiology

Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: Long-Term Results From the DOREMY Phase 2 Trial

By MedXY 06/10/2026

Long-term follow-up from the DOREMY phase 2 trial shows that reduced-dose preoperative radiotherapy for localized myxoid liposarcoma achieved excellent local control with relatively low toxicity.

news Oncology Radiology

Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: Long-Term Results from the Phase 2 DOREMY Trial

By MedXY 06/10/2026

A long-term phase 2 trial found that reduced-dose preoperative radiotherapy followed by surgery provided excellent local control and acceptable toxicity in localized myxoid liposarcoma.

Neurology news

Identification of Genetic Modifiers of Autosomal Dominant Alzheimer’s Disease: A Genome-Wide Association Study

By MedXY 06/10/2026

A genome-wide study identified three genetic modifiers of autosomal dominant Alzheimer’s disease, linking them to disease risk, earlier onset, and biomarker changes involving amyloid, tau, TDP-43, and brain aging.

Cardiology news Public Health

Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation

By MedXY 06/10/2026

A nationwide Medicare study found that women made up a declining share of TAVI patients, had more periprocedural complications, but slightly better long-term survival than men. The findings support sex-specific planning and follow-up in aortic valve care.

Diabetes & Endocrinology news Radiology

Acromegaly Diagnosis

By MedXY 06/10/2026

Acromegaly is often diagnosed late because symptoms are subtle. Serum IGF-I is the best screening test, OGTT confirms GH excess, and MRI localizes pituitary tumors. New AI and imaging tools may improve earlier detection.

AI General Surgery news

Multicenter Validation Suggests MySurgeryRisk Can Accurately Predict Major Postoperative Complications and In-Hospital Mortality Across Diverse Hospitals

By MedXY 06/10/2026

In a 14-institution cohort of more than 508,000 operations, MySurgeryRisk maintained high discrimination for ICU admission, mechanical ventilation, acute kidney injury, and in-hospital mortality using routine electronic health record data.

$Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus$

Critical Care Neurology news

Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus

By MedXY 06/10/2026

This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.

news Oncology

The Oncology Care Model and Starting Systemic Therapy for Cancer

By MedXY 06/10/2026

A Medicare-based study found the Oncology Care Model did not increase systemic therapy starts for newly diagnosed cancer and was linked to less treatment initiation and lower spending in poor-prognosis cancer.