news – Page 7 – Medxy AI

VPS13D: A Crucial Regulator of Organelle Contact Sites and Lipid Metabolism in Alcohol-Associated Steatohepatitis

By MedXY 09/19/2026

VPS13D protects against alcohol-induced liver injury by maintaining mitochondria-ER contact sites, regulating phospholipid balance and promoting VLDL secretion, thus mitigating steatosis and inflammation in alcoholic hepatitis.

Allergy & Immunology Gastroenterology news

Unveiling the TL1A-LTα1β2/IL-22 Axis: A New Therapeutic Target in Crohn’s Disease with Perianal Fistulising Disease

By MedXY 09/19/2026

This study reveals that TL1A-activated CD4+ T cells drive distinct cellular and molecular changes in the rectal mucosa of Crohn's disease patients with perianal fistulising disease (PFD), highlighting a novel TL1A-LTα1β2/IL-22 axis independent of TNF signaling, with important therapeutic implications.

Gastroenterology General Surgery news

Balancing Safety and Recurrence: Cold vs Hot Snare Resection of Large Colorectal Polyps

By MedXY 09/19/2026

This meta-analysis of four RCTs compares cold and hot snare polypectomy for large colorectal polyps, demonstrating lower major adverse events but higher recurrence with cold resection, especially in adenomas with high-grade dysplasia.

Neurology news Radiology

Arterial Spin Labeling Hemodynamic Metrics Predict Cognitive Decline and Small Vessel Disease Progression Over 11 Years

By MedXY 09/19/2026

This study demonstrates that arterial spin labeling spatial coefficient of variation (ASL-sCoV) correlates with cerebral small vessel disease burden and predicts cognitive decline over 11 years, outperforming traditional cerebral blood flow measures.

Clinical Updates Neurology news

Inpatient Rehabilitation and Major Adverse Cardiovascular Events After Ischemic Stroke: Clinical Implications and Evidence Synthesis

By MedXY 09/19/2026

Postacute discharge to inpatient rehabilitation facilities (IRF) after acute ischemic stroke (AIS) is associated with a reduced 1-year risk of major adverse cardiovascular events (MACE) compared to discharge to home or skilled nursing facilities (SNF).

Emergency Medicine Neurology news

Emergent Interfacility Transfers for Ischemic Stroke in the U.S.: Patterns and Implications from 2016 to 2022

By MedXY 09/19/2026

This study analyzes national trends in emergent interfacility ischemic stroke transfers among Medicare beneficiaries, revealing shifts in transfer rates, patient characteristics, and hospital features associated with transferred versus nontransferred populations from 2016 to 2022.

Diabetes & Endocrinology news

New 2026 EASD Guideline: Practical, Evidence-Based Care for Diabetes Distress in Adults with Type 1 and Type 2 Diabetes

By MedXY 09/19/2026

The 2026 EASD guideline provides practical, evidence-based recommendations for routine assessment and management of diabetes distress in adults with type 1 or type 2 diabetes, including validated screening, eight Good Practice Statements, and conditional GRADE recommendations for psychological and technology-based interventions.

Diabetes & Endocrinology news Pediatrics

Machine Learning-enhanced Steroid Profiling for Rapid Diagnosis of Congenital Adrenal Steroidogenesis Disorders

By MedXY 09/19/2026

This article reviews a validated machine learning decision-tree model using LC-MS/MS steroid profiles to accurately and rapidly diagnose congenital disorders of adrenal steroidogenesis (CDAS), enhancing clinical decision-making and patient outcomes.

Diabetes & Endocrinology news Pathology & Lab Medicine

New Consensus on Testosterone Reference Ranges for Females and Children: Outcomes of the 2024 PCOS Challenge–CDC Stakeholder Meeting

By MedXY 09/19/2026

A stakeholder consensus sets a roadmap to develop standardized, age- and sex-specific testosterone reference intervals for women, adolescent girls, and children to improve diagnosis and care for androgen-related disorders.

Cardiology Critical Care news

Reducing Mortality in Cardiogenic Shock: The Impact of Hospital Capability and Transfer Strategies

By MedXY 09/19/2026

Higher hospital cardiac capability correlates with lower mortality in cardiogenic shock patients, and regionalized hub-and-spoke models mitigate the transfer penalty associated with patient instability.

Cardiology Hematology-Oncology news

Cardiovascular Risks of CAR-T Therapy in Older Adults: Insights from US Medicare Data

By MedXY 09/19/2026

Among older adults receiving CAR-T therapy, 5.8% experienced major adverse cardiovascular events (MACE), associated with increased mortality. Pre-existing cardiac conditions heightened risk, underscoring the need for cardiovascular monitoring and preventive strategies.

Cardiology news Oncology

Proteomic and Metabolomic Insights into Cardiac Remodeling in Breast Cancer Patients Undergoing Cardiotoxic Therapy

By MedXY 09/19/2026

This study identifies novel proteomic and metabolomic biomarkers linked to cardiac dysfunction and remodeling in breast cancer patients treated with cardiotoxic therapies, revealing potential pathways for early detection and intervention.

Cardiology news

Intracoronary Imaging-Guided PCI: Updated Meta-Analysis Validates Cardiovascular Outcome Benefits

By MedXY 09/19/2026

This updated meta-analysis of 28 RCTs reveals significant reductions in cardiovascular events and mortality with intracoronary imaging-guided PCI versus angiography-guided PCI, highlighting the importance of lesion and geographic factors in outcome variation.

Cardiology news

Unraveling Mitochondrial Dysfunction in RBM20-Related Dilated Cardiomyopathy: The Role of Dysregulated Ribonucleoprotein Granules

By MedXY 09/19/2026

This article reviews novel research showing how cytoplasmic mislocalization of RBM20 impairs mitochondrial function, leading to severe dilated cardiomyopathy and highlighting distinct mechanisms between gain- and loss-of-function RBM20 variants.

Cardiology news

Targeting the CCND1-PDK4 Axis to Promote Reparative Macrophage Phenotype and Mitigate Post-Myocardial Infarction Cardiac Remodeling

By MedXY 09/19/2026

This article discusses the role of cyclin D1 (CCND1) in promoting reparative macrophage transition post-myocardial infarction, highlighting its therapeutic potential in reducing adverse cardiac remodeling through metabolic reprogramming.

Critical Care Nephrology news

Unlocking the Potential of Novel Biomarkers for Acute Kidney Injury in the Critically Ill: A Comprehensive Evidence Mapping

By MedXY 09/18/2026

This article reviews over 1100 studies on novel biomarkers for acute kidney injury (AKI) in critically ill patients, highlighting their predictive, diagnostic, and management roles while identifying gaps for future clinical implementation.

Emergency Medicine news

Evaluating the Impact of Relative Value Unit-Based Compensation on Emergency Physician Performance and Operational Outcomes

By MedXY 09/18/2026

A national study examining the shift from hourly to RVU-based pay for emergency physicians found no significant changes in productivity, billing intensity, or key operational metrics, suggesting compensation models may not strongly influence clinical or service outcomes.

Internal Medicine news Nursing & care

Facilitators and Barriers of Using Smart Bedside Station Systems Among Hospitalized Patients: A Qualitative Study Based on UTAUT

By MedXY 09/18/2026

This study explores factors that promote or hinder hospitalized patients' use of Smart Bedside Station systems, revealing that nursing support and useful video education encourage use, while cognitive and workflow challenges limit sustained engagement.

Clinical Updates news Oncology

Optimizing Palliative Care for Effective Hospice Transitions in Cancer Patients: Insights from Multicenter Qualitative and Quantitative Evidence

By MedXY 09/18/2026

This review synthesizes evidence identifying critical programmatic factors, relational dynamics, and interventions enhancing hospice transitions in cancer palliative care, emphasizing collaborative oncology-palliative care relationships and integrated supportive strategies.

Internal Medicine Nephrology news

KDIGO 2026 on Anemia in CKD: Key Recommendations and Practical Guidance for Clinicians

By MedXY 09/18/2026

KDIGO 2026 updates anemia care in CKD: evidence-based thresholds for iron therapy, preference for IV iron on hemodialysis, ESA-first approach over HIF-PHIs, individualized Hb initiation, and an ESA maintenance upper Hb target <11.5 g/dL.