gut microbiome – Medxy AI

Distinct Gut Microbiome Signatures Predict Short-term Hospitalisation Risk in Cirrhosis: Insights from a Global Metagenomic Study

By MedXY 09/26/2026

This multinational study reveals that specific gut microbiome profiles significantly correlate with 90-day hospitalisation risk in cirrhosis, enhancing prognostic accuracy beyond clinical features alone.

Clinical Updates Gastroenterology news

Divergent Microbial Mechanisms and Predictive Signatures in Necrotising Enterocolitis: The Role of Gut Phages and Bacterial Resistomes

By MedXY 09/23/2026

This review synthesizes evidence on the predictive and pathogenic roles of gut phages and bacterial resistomes in necrotising enterocolitis, highlighting divergent mechanisms for early- versus late-onset disease and translational opportunities for personalized risk stratification and interventions.

Gastroenterology news Oncology

Dynamic Gut Microbiome Changes Enhance Immunotherapy Outcomes in Advanced Liver Cancer

By MedXY 09/21/2026

This longitudinal study reveals that gut microbiome remodeling during immune checkpoint inhibitor therapy in advanced liver cancer patients predicts clinical benefit, improving biomarker accuracy and survival stratification.

Gastroenterology news Pediatrics

Early Childhood Exposure to Crohn’s Disease-Affected Siblings: Implications for Gut Microbiome and Disease Susceptibility

By MedXY 08/28/2026

Childhood exposure to siblings with Crohn's disease significantly raises disease risk, linked to distinct gut microbiome changes that may drive disease onset through immune modulation.

$Fecal Microbiota Transplantation: A Promising Therapy for Steroid-Refractory Acute Graft-Versus-Host Disease$

Gastroenterology Hematology-Oncology news

Fecal Microbiota Transplantation: A Promising Therapy for Steroid-Refractory Acute Graft-Versus-Host Disease

By MedXY 08/27/2026

This retrospective multicenter study evaluates fecal microbiota transplantation (FMT) for steroid-refractory acute graft-versus-host disease (aGvHD), demonstrating a 60.5% response at day 28 and highlighting FMT's potential as a safe and effective treatment option.

Diabetes & Endocrinology news Pediatrics

Fecal Short-Chain Fatty Acids in Mother-Infant Dyads: No Direct Link to Islet Autoimmunity Development

By MedXY 08/25/2026

A longitudinal study shows no association between fecal short-chain fatty acid levels during pregnancy and early childhood with the progression to islet autoimmunity in children at risk for type 1 diabetes.

Clinical Updates news

Fermentable Fiber Subtypes in Crohn’s Disease: From Primary Prevention to Mechanistic Regulation of the Gut-Immune Axis

By MedXY 06/01/2026

Recent multi-omic and clinical evidence suggests that specific fermentable fibers, particularly β-glucan and inulin, significantly reduce Crohn's Disease risk in high-risk individuals by preserving gut barrier function and modulating the microbiome-immune axis.

Clinical Updates news

Microbiome-Mediated Prevention: The Role of Fermentable Fibers in Mitigating Crohn’s Disease Risk and Gut Barrier Dysfunction

By MedXY 06/01/2026

Recent longitudinal and multi-omic studies identify specific fermentable fibers, particularly β-glucan and inulin, as critical factors in reducing Crohn's disease risk by preserving gut barrier function and modulating the microbiome-inflammation axis.

Clinical Updates news

Fermentable Fibers and Crohn’s Disease Prevention: Multi-Omic Insights into β-Glucan, Inulin, and Gut Barrier Integrity

By MedXY 06/01/2026

Higher intake of β-glucan and inulin is linked to a 30% reduction in Crohn's Disease risk among high-risk individuals, mediated by improved gut barrier function, lower systemic inflammation markers, and specific microbial signatures.

Diabetes & Endocrinology Gastroenterology news

Duodenal Recombinant RORDEP1 Was Safe and Triggered Early Incretin-Insulin Responses in Healthy Men

By MedXY 05/26/2026

In a randomized crossover trial, short-term duodenal r-RORDEP1 infusion was well tolerated and produced early changes in GLP-1, GIP, insulin, C-peptide, glucose, and a measure of insulin sensitivity in healthy men.

news OB/GYN & Women’s Health Pathology & Lab Medicine/Bệnh học

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

By MedXY 05/20/2026

This study links PCOS-related miscarriage risk to gut microbiome changes, especially reduced Parabacteroides merdae and higher isoleucine, which may promote endometrial senescence and impair pregnancy outcomes.

Gastroenterology news Oncology

Gut Microbiome Signatures Improve Diagnosis and Prognostic Stratification in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma

By MedXY 05/07/2026

A large shotgun metagenomic study links gut dysbiosis to EBV-associated nasopharyngeal carcinoma and shows that microbial markers, especially combined with EBV markers, may strengthen diagnosis and prognostic assessment.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Gut Microbiome Signatures May Help Explain Why Gestational Diabetes Raises Later Type 2 Diabetes Risk in Hispanic/Latina Women

By MedXY 05/03/2026

In HCHS/SOL, prior gestational diabetes was linked to a proinflammatory gut microbiome, adverse metabolite patterns, and higher future type 2 diabetes risk, suggesting a plausible microbiome-mediated pathway after pregnancy.

news OB/GYN & Women's Health Oncology

Stool Biospecimen Collection in Gynecologic Oncology: New Study Demonstrates Feasibility and Identifies Provider Engagement as Key Driver

By MedXY 04/02/2026

A prospective study evaluating at-home stool collection for gut microbiome research in gynecologic oncology demonstrates implementation feasibility with 61% patient enrollment. Provider engagement emerged as the strongest predictor of participation, establishing practical benchmarks for future translational microbiome studies.

Gastroenterology news

Beyond Clinical Remission: Why Diet and Gut Signatures Remain Perturbed in Crohn’s Disease

By MedXY 03/10/2026

A multi-omic study reveals that despite effective immune suppression, Crohn's disease patients in remission exhibit persistent dietary, microbial, and metabolic abnormalities. This research highlights the critical role of ultraprocessed foods and epithelial stress in preventing total disease clearance.

Gastroenterology news Oncology

The Tryptophan Tug-of-War: How Faecalibacterium prausnitzii Counteracts Bacteroides fragilis in Colorectal Cancer

By MedXY 03/08/2026

A comprehensive multi-omics study reveals that Faecalibacterium prausnitzii metabolizes tryptophan into picolinic acid, which antagonizes the pro-tumorigenic effects of enterotoxigenic Bacteroides fragilis by down-regulating TCERG1 and CKAP2 genes, suggesting a potential dietary intervention for colorectal cancer.

Diabetes & Endocrinology Gastroenterology news

Multiomics Outperform Phenotype in Predicting Post-Diet Weight Regain and Body Composition Dynamics

By MedXY 12/31/2025

A post hoc analysis of the LEAN-TIME trial reveals that integrating gut microbiome and metabolomic data with clinical phenotypes significantly improves the prediction of weight loss and regain, offering a framework for precision weight management and personalized obesity care.

Neurology news Pediatrics

Is the Gut Microbiome Really a Key to Understanding Autism?

By MedXY 11/13/2025

A critical review highlights serious flaws in research linking gut microbiome to autism, questioning its causal role and urging more rigorous studies or reconsideration of this research path.

Diabetes & Endocrinology news Ophthalmology Pathology & Lab Medicine

Indole-3-Propionic Acid Bridges Gut Dysfunction and Diabetic Retinopathy — A Biomarker and Therapeutic Avenue

By MedXY 11/09/2025

A Gut 2025 study identifies microbially produced indole-3-propionic acid (IPA) as a protective metabolite linking restored intestinal tryptophan handling to prevention of diabetic retinopathy in mice and associates low serum IPA with retinopathy in people with type 2 diabetes.

Clinical Updates Neurology Specialties

Early-Life Gut Microbiome Maturity: A Key Regulator of Blood-Brain Barrier Integrity and Cognitive Development

By MedXY 09/29/2025

This study demonstrates that the maturity of the early-life gut microbiome influences blood-brain barrier integrity and cognitive functions, highlighting a novel therapeutic target for neurodevelopmental disorders.