Highlights
The study identifies a critical microbe-metabolite-host regulatory axis in colorectal cancer (CRC) characterized by the interaction between Faecalibacterium prausnitzii and enterotoxigenic Bacteroides fragilis.
Faecalibacterium prausnitzii converts dietary tryptophan into picolinic acid (PIA) via the enzyme 2-amino-3-carboxymuconate semialdehyde decarboxylase.
