Gut Microbiome Signatures May Help Explain Why Gestational Diabetes Raises Later Type 2 Diabetes Risk in Hispanic/Latina Women

Highlights

Among parous women in the Hispanic Community Health Study/Study of Latinos, a history of gestational diabetes mellitus was associated years later with a distinct gut microbial profile, including enrichment of potentially proinflammatory taxa and depletion of short-chain fatty acid-producing species.

Fifteen serum metabolites tracked consistently with both prior gestational diabetes and the gestational diabetes-related microbiome; nine of these metabolites were also associated with glycaemic traits and incident type 2 diabetes.

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