Epigenetics – Medxy AI

DNA Methylation Signatures Distinguish Gout from Asymptomatic Hyperuricaemia and Align with Genetic Risk at Immune-Metabolic Loci

By MedXY 10/29/2026

This study identifies specific DNA methylation patterns in blood that differentiate gout patients from those with asymptomatic hyperuricaemia and normouricaemic controls, linking epigenetic changes to immune-metabolic genetic risk factors and offering potential for molecular disease stratification.

For graphical abstract description, please refer to the textual abstract.

Cardiology news

Palmitic Acid and Cardiac Hypertrophy: Unveiling the Epigenetic Memory Driving Heart Failure

By MedXY 10/16/2026

This article explores how palmitic acid induces a pro-hypertrophic memory in cardiomyocytes through epigenetic regulation involving KDM5A and H3K4me3 modifications, driving cardiac hypertrophy and heart failure, and highlights potential therapies targeting this pathway.

Cardiology news Pathology & Lab Medicine/Bệnh học

Unraveling Abdominal Aortic Aneurysm: Epigenetic Links to Inflammation and Lipid Metabolism

By MedXY 10/04/2026

An epigenome-wide study reveals that DNA methylation markers linked to inflammatory pathways and blood lipid traits play a causal role in abdominal aortic aneurysm development, offering potential for improved risk prediction and therapeutic targeting.

Hematology-Oncology news Oncology

Targeting NSD2 Degradation: A Novel Therapeutic Avenue for High-Risk t(4;14) Multiple Myeloma

By MedXY 09/30/2026

This article explores the discovery of NSD2-ligand-directed degrader (NSD2-LDD), a promising targeted therapy that degrades oncogenic NSD2 in t(4;14) multiple myeloma, reversing malignant epigenomic programs and improving disease outcomes in preclinical models.

Infectious Diseases news

HBV-Induced Immunosuppressive Macrophages: Metabolic and Epigenetic Pathways Driving Chronic Hepatitis B Persistence

By MedXY 09/21/2026

This article reviews recent evidence on how HBV manipulates monocyte-to-macrophage differentiation through metabolic and epigenetic reprogramming, facilitating immunosuppression and chronic infection.

Cardiology news Respiratory

Unveiling PUS7’s Role in Pulmonary Hypertension: A Novel Epigenetic Driver of Vascular Remodeling

By MedXY 09/04/2026

This article explores how PUS7-induced pseudouridylation of TGFBI mRNA promotes pulmonary hypertension via epigenetic regulation, revealing promising new therapeutic targets.

Hematology-Oncology news Pathology & Lab Medicine

Enhancing Prognostic Accuracy in Acute Myeloid Leukemia through DNA Methylation Signatures

By MedXY 08/28/2026

DNA methylation profiling in AML patients reveals epigenetic subtypes that mirror genetic mutations, improving risk stratification and outcome prediction beyond standard genetic markers.

Gastroenterology news

Epigenetic Silencing of Hepatocyte FoxO1: A Novel Mechanism Disrupting Liver Immune Balance and Driving Inflammation

By MedXY 08/18/2026

Epigenetic repression of hepatocyte FoxO1 disrupts immune homeostasis in the liver, promoting inflammation via altered NKT cell regulation, revealing promising therapeutic targets for inflammatory liver diseases.

Cardiology news Pathology & Lab Medicine

Blood DNA Methylation Maps Atherosclerosis Across Vascular Beds: Strong Signals, but Mostly a Record of Cumulative Risk Exposure

By MedXY 06/15/2026

In 2 prospective cohorts, blood DNA methylation was associated with carotid, coronary, and peripheral atherosclerosis, but most signals overlapped with smoking and cardiometabolic risk factors rather than vessel-specific biology.

Family Medicine & Nutrition news Specialties

Beyond the Wrinkles: Unveiling 3 Hidden Accelerators of Aging After 50

By MedXY 09/11/2025

Stanford scientists identify smoking, cadmium, and lead as major environmental factors accelerating biological aging, revealing new insights into how lifestyle and environment shape health beyond genetics.

Family Medicine & Nutrition news Specialties

Exploring the Therapeutic Potential of Betaine and Its Derivatives in Cancer Treatment: From Mechanisms to Clinical Implications

By MedXY 08/30/2025

Betaine, a natural methyl donor with antioxidant and anti-inflammatory properties, demonstrates promising anticancer activity across multiple cancer types. Its derivatives and nanotechnology-assisted delivery systems enhance therapeutic efficacy and safety, offering innovative avenues for cancer management.