Racial and Ethnic Disparities in Treatment Initiation and Survival Among Patients With Endometrial Cancer: Socioeconomic Modifiers and Clinical Implications
Posted inClinical Updates news OB/GYN & Women's Health Oncology

Racial and Ethnic Disparities in Treatment Initiation and Survival Among Patients With Endometrial Cancer: Socioeconomic Modifiers and Clinical Implications

This review synthesizes recent evidence demonstrating persistent racial and ethnic disparities in treatment initiation and survival among patients with advanced endometrial cancer, highlighting the critical influence of socioeconomic status and social determinants on outcomes.
Genetic Testing in Endometrial Cancer: Prevalence of Pathogenic Germline Variants and Implications for Clinical Practice in a Diverse Community Cohort
Posted innews OB/GYN & Women's Health Oncology

Genetic Testing in Endometrial Cancer: Prevalence of Pathogenic Germline Variants and Implications for Clinical Practice in a Diverse Community Cohort

In a large, diverse cohort of women with endometrial cancer, 11.9% harbored pathogenic germline variants, including Lynch syndrome and homologous recombination deficiency-related mutations. Testing at diagnosis identified most Lynch syndrome cases, highlighting the need for expanded genetic screening strategies.
Molecular Complexity of Endometrial Cancer: How Biomarker Patterns Vary Across Tumor Stages, Histology, and Molecular Subtypes
Posted innews OB/GYN & Women's Health Oncology

Molecular Complexity of Endometrial Cancer: How Biomarker Patterns Vary Across Tumor Stages, Histology, and Molecular Subtypes

A real-world study of 671 endometrial cancer patients reveals significant molecular heterogeneity. PTEN, ARID1A, and PIK3CA are the most prevalent biomarkers, while TP53 mutations and ERBB2 amplification cluster in advanced-stage and non-endometrioid tumors. The findings underscore the need for comprehensive molecular profiling to guide personalized treatment strategies.
Immunotherapy Shows Consistent Efficacy in Recurrent Gynecologic Cancers Regardless of Prior Radiation Field Location
Posted innews OB/GYN & Women's Health Oncology

Immunotherapy Shows Consistent Efficacy in Recurrent Gynecologic Cancers Regardless of Prior Radiation Field Location

This retrospective study challenges the assumption that prior radiation limits immunotherapy effectiveness in recurrent endometrial and cervical cancers, finding no significant difference in response rates or survival outcomes based on recurrence location relative to previous radiotherapy fields.