Highlight
- Serum GLP-1 levels decrease progressively from endometrial polyp through hyperplasia to endometrial cancer in obese, non-diabetic women.
- Lower GLP-1 levels independently predict presence of endometrial cancer with high diagnostic accuracy (AUC 0.94).
- GLP-1 correlates negatively with age and systemic inflammation marker CRP, but its cancer association persists after adjustment.
- Potential utility of GLP-1 as an adjunct biomarker for risk stratification in obese women with abnormal uterine bleeding.
