Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss

Combining aerobic and resistance exercise with diet-induced weight loss in obese older adults significantly improves insulin secretion, preserves CNTFRα levels, and increases IGF-1, enhancing metabolic and physical function.
Hydroxytyrosol Supplementation Enhances Antioxidant and Anti-Inflammatory Status in Overweight Prediabetic Adults: Insights from a Randomized Controlled Trial
Posted inDiabetes & Endocrinology Family Medicine & Nutrition news Specialties

Hydroxytyrosol Supplementation Enhances Antioxidant and Anti-Inflammatory Status in Overweight Prediabetic Adults: Insights from a Randomized Controlled Trial

A 16-week randomized trial demonstrates that daily hydroxytyrosol supplementation significantly reduces oxidative stress and inflammatory markers in overweight individuals with prediabetes, highlighting its potential in preventing aging-related diseases.
Tai Chi and Cognitive Enhancement in Older Adults With Type 2 Diabetes Mellitus: Evidence From Randomized Controlled Trials Using Wearable Technology in mHealth Models
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Tai Chi and Cognitive Enhancement in Older Adults With Type 2 Diabetes Mellitus: Evidence From Randomized Controlled Trials Using Wearable Technology in mHealth Models

Emerging RCT evidence supports Tai Chi's superior benefits over fitness walking in improving cognitive function and sleep quality among older adults with type 2 diabetes and mild cognitive impairment, facilitated by telemedicine and wearable devices.
Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity

Combining aerobic and resistance exercise with diet-induced weight loss in older adults with obesity significantly improves insulin secretion, metabolic health, and physical function, likely mediated by ciliary neurotrophic factor receptor preservation and increased IGF-1 levels.
Enhancing Metformin Efficacy and Tolerability in Prediabetes Through a Fermentable Carbohydrate-Rich Diet
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Enhancing Metformin Efficacy and Tolerability in Prediabetes Through a Fermentable Carbohydrate-Rich Diet

A fermentable carbohydrate-enriched diet combined with metformin improves postprandial glycaemia, enhances GLP-1 secretion, and positively alters gut microbiota in prediabetic individuals, offering a personalized nutrition-pharmacology strategy for diabetes prevention.
Dose-Dependent Enhancement of L-Tryptophan-Induced Gut Hormone Secretion and Appetite Suppression by Intraduodenal Calcium in Obesity
Posted inClinical Updates Family Medicine & Nutrition Gastroenterology news Specialties

Dose-Dependent Enhancement of L-Tryptophan-Induced Gut Hormone Secretion and Appetite Suppression by Intraduodenal Calcium in Obesity

Intraduodenal calcium at doses up to 1000 mg amplifies the anorexigenic effects of L-tryptophan by boosting gut hormones CCK, GLP-1, and PYY, reducing energy intake in obese males, highlighting a novel adjunctive approach for appetite regulation in obesity management.
Personalized Anti-Inflammatory Diet Modulates Gut Microbiome and Metabolome to Alleviate Osteoarthritis Pain
Posted inClinical Updates Family Medicine & Nutrition Orthopedics Specialties

Personalized Anti-Inflammatory Diet Modulates Gut Microbiome and Metabolome to Alleviate Osteoarthritis Pain

A 4-week anti-inflammatory dietary intervention in knee osteoarthritis patients led to targeted shifts in gut microbiota and metabolite profiles associated with significant pain reduction, highlighting the potential of microbiome-informed nutritional strategies for OA management.
Nutritional Intervention in Chronic Heart Failure: Enhancing Functional Capacity and Nutritional Status without Major Clinical Outcome Impact
Posted inDiabetes & Endocrinology Family Medicine & Nutrition news Specialties

Nutritional Intervention in Chronic Heart Failure: Enhancing Functional Capacity and Nutritional Status without Major Clinical Outcome Impact

A prespecified subanalysis of the PACMAN-HF trial demonstrates that individualized nutritional interventions in chronic heart failure patients at risk of malnutrition improve nutritional status and functional capacity but do not significantly affect mortality or heart failure hospitalizations.
Prepregnancy Time-Restricted Eating and Exercise Training Do Not Improve Glycaemic Control in High-Risk Gestational Diabetes: Insights from the BEFORE THE BEGINNING Trial
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition Specialties

Prepregnancy Time-Restricted Eating and Exercise Training Do Not Improve Glycaemic Control in High-Risk Gestational Diabetes: Insights from the BEFORE THE BEGINNING Trial

A randomized trial investigating time-restricted eating and exercise before and during pregnancy found no significant improvement in glucose tolerance at 28 weeks gestation among individuals at elevated risk of gestational diabetes.
Dynamic Effects of Short-Term Dietary Energy Loads on Fecal Serotonin, Gut Microbiome Tryptophanase, and Energy Absorption: Insights from a Randomized Crossover Trial
Posted inAllergy & Immunology Family Medicine & Nutrition news Specialties

Dynamic Effects of Short-Term Dietary Energy Loads on Fecal Serotonin, Gut Microbiome Tryptophanase, and Energy Absorption: Insights from a Randomized Crossover Trial

Short-term alterations in dietary energy intake significantly impact fecal serotonin, gut microbiome tryptophanase activity, and energy absorption, highlighting a complex interaction that may influence metabolic health.