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HERZCHECK is the first large-scale, multicenter cross-sectional study to implement a fully mobile, telemedically supervised, contrast-free cardiac magnetic resonance imaging (MRI) screening algorithm for subclinical preheart failure (pre-HF) in rural and underresourced regions. The study revealed a high prevalence (22.7%) of subclinical pre-HF among at-risk individuals aged 40–69 with cardiovascular risk factors. Importantly, global longitudinal strain (GLS)-based screening identified subclinical pre-HF approximately 6.7 years earlier than symptom-based diagnosis under standard care, offering a critical window for targeted preventive interventions.
