Highlight
Patients with prior abdominal solid organ transplantation (SOT) experience significantly better 30-day survival following sepsis compared to non-SOT patients despite their chronic immunosuppressed state. This survival benefit is accompanied by a distinct immunological signature characterized by reduced systemic pro-inflammatory cytokines (IL-6, TNF-α), elevated IL-18, and preserved innate immune markers such as high monocytic HLA-DR expression. Proteomic and metabolomic analyses reveal enrichment of innate immune, complement, and lipid metabolic pathways alongside immunometabolic alterations including increased GLUT1 expression and enhanced mitochondrial transcription factor interactions. These findings highlight a unique immunometabolic phenotype in septic SOT patients that may underlie their improved clinical outcomes.
Study Background
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