Highlight
- Daily feelings of guilt related to diabetes self-management act as a pivotal trigger of other negative emotional experiences in people with diabetes.
- In type 1 diabetes, guilt precedes increased feelings of loneliness, overwhelm, restriction, and burden from hyperglycaemia the following day.
- In type 2 diabetes, feelings of guilt more often occur as a result of other negative burdens such as loneliness and hypoglycaemia burden.
- Higher interconnectivity among daily diabetes-specific burdens predicts incident diabetes distress and depressive symptoms, with guilt and feeling restricted as key predictors.
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For clinical reference; use professional judgment.

