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空間転写体遺伝子学

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空間転写体遺伝子学

Cardiac Sarcoidosis May Be Driven by a Heart-Resident Autoimmune B-Cell Axis Linked to Periplakin

Posted inAllergy & Immunology Cardiology news

Cardiac Sarcoidosis May Be Driven by a Heart-Resident Autoimmune B-Cell Axis Linked to Periplakin

Posted by

By MedXY 06/10/2026

Single-cell and spatial transcriptomics suggest that cardiac sarcoidosis evolves through region-specific inflammatory programs and intracardiac B-cell autoimmunity, with periplakin emerging as a candidate autoantigen.

Spatial Profiling of Resistance Mechanisms in HER2-Positive Gastric Cancer: Insights from Patient-Matched Analysis

Posted inGastroenterology news Oncology

Spatial Profiling of Resistance Mechanisms in HER2-Positive Gastric Cancer: Insights from Patient-Matched Analysis

Posted by

By MedXY 03/27/2026

This report examines spatial transcriptomic data from HER2+ gastric cancer patients to identify resistance mechanisms to trastuzumab and T-DXd, including EMT and ERAD pathway activation.

Pre-Transplant Left Atrial Volume Index as a Predictor of One-Year Morbidity after Kidney Transplantation: Insights and Implications
Normothermic Regional Perfusion: A Paradigm Shift in Pancreas and Islet Transplantation from DCD Donors
A Practical Framework for Pyoderma Gangrenosum: Expert Consensus Defines Phenotypes and Modifiers
Early Prediction of Dupilumab Efficacy in Facial Atopic Dermatitis via Reflectance Confocal Microscopy and Deep Learning
Optimizing Breast Augmentation Through Tissue Preservation and 3D Geometric Analysis: Clinical Insights and Outcomes

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