Septic Shock in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: Outcomes, Prognostic Factors, and Clinical Implications from a Multicenter ICU Cohort
Posted inCritical Care Hematology-Oncology news

Septic Shock in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: Outcomes, Prognostic Factors, and Clinical Implications from a Multicenter ICU Cohort

Septic shock following allogeneic hematopoietic stem-cell transplantation has a high 90-day mortality rate of 63%, strongly influenced by illness severity, fungal infection, and neutropenia. Early aminoglycoside use shows complex associations with survival, highlighting the need for nuanced treatment strategies.
Early Red Blood Cell Transfusion Strategy in Septic Shock Among Cancer Patients: Insights from the TRANSPORT Randomized Controlled Trial
Posted inClinical Updates Critical Care news Oncology

Early Red Blood Cell Transfusion Strategy in Septic Shock Among Cancer Patients: Insights from the TRANSPORT Randomized Controlled Trial

The TRANSPORT trial showed no superiority of liberal versus restrictive RBC transfusion in septic shock patients with cancer, highlighting no mortality benefit and increased thrombotic events with liberal strategy, underscoring the need for individualized transfusion approaches.
Evaluating Renal Resistive Index Responsiveness to MAP Targets in Early Septic Shock: Clinical Implications and Physiologic Insights
Posted inCritical Care Nephrology news

Evaluating Renal Resistive Index Responsiveness to MAP Targets in Early Septic Shock: Clinical Implications and Physiologic Insights

This study explores whether renal resistive index (RRI) changes during a transient elevation of mean arterial pressure (MAP) can guide individualized MAP targets to optimize renal function in early septic shock, finding that RRI decrease does not predict improved outcomes with higher MAP, while lack of RRI decrease may identify patients benefiting from MAP elevation.
Targeting Capillary Refill Time in Early Septic Shock Reduced Duration of Organ Support: Key Findings from ANDROMEDA‑SHOCK‑2
Posted inCritical Care news

Targeting Capillary Refill Time in Early Septic Shock Reduced Duration of Organ Support: Key Findings from ANDROMEDA‑SHOCK‑2

ANDROMEDA‑SHOCK‑2 randomized 1,501 patients with early septic shock to a personalized CRT‑guided hemodynamic protocol versus usual care. A hierarchical composite outcome favored the CRT strategy (win ratio 1.16; 95% CI 1.02–1.33; P = .04), driven mainly by shorter duration of organ support rather than lower mortality.